高胆固醇摄入与 2 型糖尿病风险升高相关——一项荟萃分析。
High cholesterol intake is associated with elevated risk of type 2 diabetes mellitus - a meta-analysis.
机构信息
Department of Nutrition and Food Science, Graduate School of Humanities and Sciences, Ochanomizu University, Japan.
Department of Health Management Center, Mito Kyodo General Hospital, Japan; Department of Internal Medicine, Niigata University Faculty of Medicine, Japan.
出版信息
Clin Nutr. 2014 Dec;33(6):946-50. doi: 10.1016/j.clnu.2014.03.001. Epub 2014 Mar 13.
BACKGROUND & AIMS: Some foods rich in cholesterol are associated with high risk of type 2 diabetes (T2D). To confirm the association between dietary cholesterol intake and T2D risk, we performed a meta-analysis of observational studies.
METHODS
We searched for longitudinal studies that provided data on the relative risk (RR) for T2D in relation to the cholesterol intake level using MEDLINE (from 1950 for July 10, 2013) and EMBASE (from 1974 to July 10, 2013). The RR for the highest vs. lowest cholesterol intake category or for an increment of 100 mg/day in cholesterol consumption was pooled with an inverse-variance method.
RESULTS
Five studies met the inclusion criteria. Compared with the lowest category, the highest category had a significantly higher association with T2D risk (RR [95% confidence interval (CI)], 1.25 [1.16-1.36]). The pooled RR for a 100-mg/day increment was also significant (RR [95% CI], 1.11 [1.06-1.15]).
CONCLUSION
Current meta-analysis suggested that high intake of cholesterol was positively associated with future T2D risk.
背景与目的
一些富含胆固醇的食物与 2 型糖尿病（T2D）的发病风险较高相关。为了明确膳食胆固醇摄入量与 T2D 风险之间的关联，我们对观察性研究进行了荟萃分析。
方法
我们检索了从 1950 年至 2013 年 7 月 10 日 MEDLINE 和从 1974 年至 2013 年 7 月 10 日 EMBASE 上关于胆固醇摄入量与 T2D 风险关系的前瞻性研究，提供胆固醇摄入量水平与 T2D 相对风险（RR）的数据。采用逆方差法对最高与最低胆固醇摄入量类别或胆固醇摄入量每天增加 100mg 的 RR 进行合并。
结果
有 5 项研究符合纳入标准。与最低类别相比，最高类别与 T2D 风险显著相关（RR [95%置信区间（CI）]，1.25 [1.16-1.36]）。每天增加 100mg 胆固醇的合并 RR 也有统计学意义（RR [95% CI]，1.11 [1.06-1.15]）。
结论
目前的荟萃分析表明，高胆固醇摄入与未来 T2D 风险呈正相关。
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