Heart and Vascular Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Heart and Vascular Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Nutr Metab Cardiovasc Dis. 2014 Jul;24(7):799-805. doi: 10.1016/j.numecd.2014.02.007. Epub 2014 Mar 1.
Habitual physical activity is understood to help prevent type 2 diabetes and atherosclerotic cardiovascular disease via beneficial effects on both metabolism and the vascular system. However, individuals do not have uniform cardiometabolic responses to physical activity. Here we explore the extent to which variation in the proliferator-activated receptor-alpha (PPARα) gene, which modulates carbohydrate and lipid metabolism, vascular function, and inflammation, predicts the overall cardiometabolic risk (CMR) profile of individuals engaging in various levels of physical activity.
917 unrelated, community volunteers (52% female, of Non-Hispanic European ancestry) aged 30-54 years, participated in the cross-sectional study. Subjects were genotyped for 5 single nucleotide polymorphisms in the PPARα gene, from which common haplotypes were defined. A continuous measure of CMR was calculated as an aggregate of 5 traditional risk factors: waist circumference, resting blood pressure, fasting serum triglycerides, HDL-cholesterol and glucose. Regression models were used to examine the main and interactive effects of physical activity and genetic variation on CMR. One common PPARα haplotype (H-23) was associated with a higher CMR. This association was moderated by daily physical activity (B = -0.11, SE = 0.053, t = -2.05, P = 0.04). Increased physical activity was associated with a steeper reduction of CMR in persons carrying the otherwise detrimental H-23 haplotype.
Variations in the PPARα gene appear to magnify the cardiometabolic benefits of habitual physical activity.
有研究表明，有规律的体育活动通过对代谢和血管系统的有益影响，可以帮助预防 2 型糖尿病和动脉粥样硬化性心血管疾病。然而，个体对体育活动的代谢和心血管反应并不一致。在这里，我们探讨了调节碳水化合物和脂质代谢、血管功能和炎症的过氧化物酶体增殖物激活受体-α（PPARα）基因的变异在多大程度上预测了从事不同水平体育活动的个体的整体心血管代谢风险（CMR）特征。
917 名无血缘关系的社区志愿者（52%为女性，非西班牙裔欧洲血统）年龄在 30-54 岁之间，参加了这项横断面研究。对这些志愿者的 5 个单核苷酸多态性进行了 PPARα 基因的基因分型，从中定义了常见的单倍型。通过将 5 个传统风险因素（腰围、静息血压、空腹血清甘油三酯、高密度脂蛋白胆固醇和血糖）进行综合计算得出连续的 CMR 衡量标准。采用回归模型检验了体育活动和遗传变异对 CMR 的主要和交互作用。一个常见的 PPARα 单倍型（H-23）与更高的 CMR 相关。这种关联受到日常体育活动的调节（B=-0.11，SE=0.053，t=-2.05，P=0.04）。在携带其他有害 H-23 单倍型的人群中，增加体育活动与 CMR 的降低幅度更大有关。
PPARα 基因的变异似乎放大了习惯性体育活动对心血管代谢的益处。
