Beckerman Pazit, Ko Yi-An, Susztak Katalin
Renal Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Nephrol Dial Transplant. 2014 Oct;29(10):1821-7. doi: 10.1093/ndt/gfu026. Epub 2014 Mar 27.
Only a few percent of the 3 billion pairs of chemical letters in the human genome is responsible for protein-coding sequences. Recent advances in the field of epigenomics have helped us to understand how most of the remaining sequences are responsible for gene regulation at baseline and in disease conditions. Here we discuss recent advances in the area of epigenetics--specifically in cytosine modifications--and its application in the field of nephrology.
人类基因组中30亿对化学字母中只有百分之几负责蛋白质编码序列。表观基因组学领域的最新进展帮助我们了解了其余大部分序列如何在基线状态和疾病状态下负责基因调控。在此，我们讨论表观遗传学领域——特别是胞嘧啶修饰方面——的最新进展及其在肾脏病学领域的应用。
