Zhang Lei, Fok Jacqueline H L, Davies Faith E
Oncotarget. 2014 Mar 15;5(5):1132-48. doi: 10.18632/oncotarget.1584.
Heat shock proteins are molecular chaperones with a central role in protein folding and cellular protein homeostasis. They also play major roles in the development of cancer and in recent years have emerged as promising therapeutic targets. In this review, we discuss the known molecular mechanisms of various heat shock protein families and their involvement in cancer and in particular, multiple myeloma. In addition, we address the current progress and challenges in pharmacologically targeting these proteins as anti-cancer therapeutic strategies.
热休克蛋白是分子伴侣，在蛋白质折叠和细胞蛋白质稳态中起核心作用。它们在癌症发展中也发挥着重要作用，近年来已成为有前景的治疗靶点。在本综述中，我们讨论了各种热休克蛋白家族的已知分子机制及其在癌症特别是多发性骨髓瘤中的作用。此外，我们阐述了将这些蛋白作为抗癌治疗策略进行药物靶向的当前进展和挑战。
