Neven Patrick, Markopoulos Christos, Tanner Minna, Marty Michel, Kreienberg Rolf, Atkins Louise, Franquet Ann, Gnant Michael, Neciosup Silvia, Tesarova Petra, Barni Sandro, Deschamp Veronique
Multidisciplinary Breast Centre and Gynaecological Oncology, UZ Leuven, Leuven, Belgium.
Breast Unit, Athens University Medical School and Department of Surgery, Athens, Greece.
Breast. 2014 Aug;23(4):393-9. doi: 10.1016/j.breast.2014.02.009. Epub 2014 Mar 24.
The CARIATIDE study was designed to assess the impact of educational materials (EMs) on compliance and persistence rates with aromatase inhibitor (AI) treatment in postmenopausal women with hormone-receptor-positive early breast cancer. Patients were randomized to standard AI treatment (Group A; N = 1379) or standard AI treatment plus EMs containing information on a range of breast-cancer-related topics (Group B; N = 1379). Standardized questionnaires assessed investigator-perceived levels of care and evaluated patient compliance and behavior. At 1 year, there was no significant difference in compliance between Group A and Group B (81% vs. 82%, p = 0.4524). However, higher compliance in patients receiving EMs was observed in Sweden/Finland (p = 0.0246). Compliance with initial AI and persistence rate were not significantly altered by EM. Other factors associated with improved compliance, irrespective of EMs, e.g. administration of chemotherapy were identified.
CARIATIDE研究旨在评估教育材料（EMs）对激素受体阳性早期乳腺癌绝经后女性芳香化酶抑制剂（AI）治疗依从性和持续率的影响。患者被随机分为接受标准AI治疗组（A组；N = 1379）或接受标准AI治疗加包含一系列乳腺癌相关主题信息的EMs组（B组；N = 1379）。标准化问卷评估研究者感知的护理水平，并评估患者的依从性和行为。1年后，A组和B组的依从性无显著差异（81%对82%，p = 0.4524）。然而，在瑞典/芬兰观察到接受EMs的患者依从性更高（p = 0.0246）。EMs未显著改变初始AI的依从性和持续率。还确定了与依从性改善相关的其他因素，无论是否有EMs，如化疗的使用情况。
