Nagle R B
Department of Pathology, University of Arizona, Tucson 85724.
Am J Clin Pathol. 1989 Apr;91(4 Suppl 1):S14-8.
The use of antibodies specific for the various types of intermediate filament proteins has become an important part of the immunohistochemical approach to surgical pathology. These proteins are expressed in a cell lineage-specific pattern, which is reproduced with great fidelity even in poorly differentiated neoplasms. The historic discovery, embryology, and structure of these proteins are reviewed. A brief discussion of the major applications and precautions in the choice and use of these antibodies is presented.
