Lehto V P, Miettinen M, Virtanen I
Arch Geschwulstforsch. 1986;56(4):283-98.
Most mammalian nucleated cells contain a cytoplasmic fibril system called intermediate filaments. Unlike other cytoskeletal proteins, the subunit proteins of intermediate filaments show a remarkable cell-type-specificity in their expression: mesenchymal, muscle, epithelial, glial and neuronal cells containing each their cell type specific filaments. In this review we discuss the possibilities to use antibodies to these filaments in the diagnosis and histogenetic analysis of human tumors. This approach is based on findings which indicate that these filaments retain their cell-type specific expression also in tumors.
大多数哺乳动物的有核细胞都含有一种称为中间丝的细胞质纤维系统。与其他细胞骨架蛋白不同，中间丝的亚基蛋白在表达上表现出显著的细胞类型特异性：间充质细胞、肌肉细胞、上皮细胞、神经胶质细胞和神经元细胞各自含有其细胞类型特异性的细丝。在这篇综述中，我们讨论了使用针对这些细丝的抗体进行人类肿瘤诊断和组织发生学分析的可能性。这种方法基于一些研究结果，这些结果表明这些细丝在肿瘤中也保留了其细胞类型特异性表达。
