Beijing Engineering Research Center for BioNanotechnology & Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, Beijing, 100190, China.
Lab Chip. 2014 May 21;14(10):1673-7. doi: 10.1039/c4lc00080c. Epub 2014 Mar 27.
This report describes a straightforward but robust tubing method for connecting polydimethylsiloxane (PDMS) microfluidic devices to external equipment. The interconnection is irreversible and can sustain a pressure of up to 4.5 MPa that is characterized experimentally and theoretically. To demonstrate applications of this high-pressure tubing technique, we fabricate a semicircular microfluidic channel to implement a high-throughput, size-controlled synthesis of poly(lactic-co-glycolic acid) (PLGA) nanoparticles ranging from 55 to 135 nm in diameter. This microfluidic device allows for a total flow rate of 410 mL h(-1), resulting in enhanced convective mixing which can be utilized to precipitate small size nanoparticles with a good dispersion. We expect that this tubing technique would be widely used in microfluidic chips for nanoparticle synthesis, cell manipulation, and potentially nanofluidic applications.
本报告描述了一种将聚二甲基硅氧烷（PDMS）微流控器件与外部设备连接的简单但可靠的管连接方法。这种连接是不可逆的，可以承受高达 4.5 MPa 的压力，这在实验和理论上都有描述。为了展示这种高压管连接技术的应用，我们制作了一个半圆形微流道，以实现高通量、粒径可控的聚（乳酸-共-乙醇酸）（PLGA）纳米粒子的合成，其粒径范围为 55 至 135nm。这种微流控器件允许总流速达到 410 mL h(-1)，从而增强了对流混合，可用于沉淀小粒径的纳米粒子并获得良好的分散性。我们预计，这种管连接技术将广泛应用于用于纳米粒子合成、细胞操作以及潜在的纳流控应用的微流控芯片中。
