CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, Beijing, 100190, China.
Nanoscale. 2013 Jun 21;5(12):5262-5. doi: 10.1039/c3nr01289a.
This report demonstrates a microfluidic origami chip to synthesize monodisperse, doxorubicin-loaded poly(lactic-co-glycolic acid) nanoparticles with diameters of ~100 nm, a size optimized for cellular uptake and anticancer efficacy, but difficult to achieve with existing approaches. This three-dimensional design in a microchannel may allow for the fabrication of polymeric nanoparticles in this size regime with ease.
本报告展示了一种微流控折纸芯片，用于合成单分散、载有阿霉素的聚（乳酸-共-乙醇酸）纳米粒，其直径约为 100nm，这是一种优化的细胞摄取和抗癌效果的尺寸，但用现有方法很难实现。这种微通道中的三维设计可能使得在这个尺寸范围内制备聚合物纳米粒变得更加容易。
