血清锌水平降低是衰老的结果，而非阿尔茨海默病的结果。
Decreased serum zinc is an effect of ageing and not Alzheimer's disease.
作者信息
Rembach Alan, Hare Dominic J, Doecke James D, Burnham Samantha C, Volitakis Irene, Fowler Christopher J, Cherny Robert A, McLean Catriona, Grimm Rudolf, Martins Ralph, Ames David, Masters Colin L, Bush Ashley I, Roberts Blaine R
机构信息
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia.
出版信息
Metallomics. 2014 Jul;6(7):1216-9. doi: 10.1039/c4mt00060a.
We examined the distribution of zinc in the periphery (erythrocytes and serum) in a large, well-characterised cohort, the Australian Imaging, Biomarkers and Lifestyle (AIBL) study, in order to determine if there is systemic perturbation in zinc homeostasis in Alzheimer's disease (AD). We observed an age dependent decrease in serum zinc of approximately 0.4% per year. When correcting for the age dependent decline in serum zinc no significant difference between healthy controls (HC), mildly cognitively impaired (MCI) or AD subjects was observed.
我们在一个规模大、特征明确的队列——澳大利亚影像、生物标志物和生活方式（AIBL）研究中，检测了锌在周围组织（红细胞和血清）中的分布，以确定阿尔茨海默病（AD）患者的锌稳态是否存在全身性紊乱。我们观察到血清锌随年龄增长每年下降约0.4%。在校正血清锌随年龄的下降后，未观察到健康对照（HC）、轻度认知障碍（MCI）或AD受试者之间存在显著差异。
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