Shah Harsh, Dehghani Fereshteh, Ramezan Marjan, Gannaban Ritchel B, Haque Zobayda Farzana, Rahimi Fatemeh, Abbasi Soheil, Shin Andrew C
Neurobiology of Nutrition Laboratory, Department of Nutritional Sciences, College of Human Sciences, Texas Tech University, Lubbock, TX 79409, USA.
Department of Nutritional Sciences, School of Nutrition and Food Sciences, Kermanshah University of Medical Sciences, Kermanshah 67158-47141, Iran.
Antioxidants (Basel). 2023 Feb 8;12(2):415. doi: 10.3390/antiox12020415.
Alzheimer's disease (AD) is the most common type of dementia that affects millions of individuals worldwide. It is an irreversible neurodegenerative disorder that is characterized by memory loss, impaired learning and thinking, and difficulty in performing regular daily activities. Despite nearly two decades of collective efforts to develop novel medications that can prevent or halt the disease progression, we remain faced with only a few options with limited effectiveness. There has been a recent growth of interest in the role of nutrition in brain health as we begin to gain a better understanding of what and how nutrients affect hormonal and neural actions that not only can lead to typical cardiovascular or metabolic diseases but also an array of neurological and psychiatric disorders. Vitamins and minerals, also known as micronutrients, are elements that are indispensable for functions including nutrient metabolism, immune surveillance, cell development, neurotransmission, and antioxidant and anti-inflammatory properties. In this review, we provide an overview on some of the most common vitamins and minerals and discuss what current studies have revealed on the link between these essential micronutrients and cognitive performance or AD.
阿尔茨海默病（AD）是最常见的痴呆类型，影响着全球数百万人。它是一种不可逆的神经退行性疾病，其特征是记忆力减退、学习和思维能力受损，以及难以进行日常常规活动。尽管近二十年来人们共同努力开发能够预防或阻止疾病进展的新型药物，但我们仍然只有少数几种效果有限的选择。随着我们开始更好地理解营养素是什么以及如何影响激素和神经活动，而这些活动不仅会导致典型的心血管或代谢疾病，还会引发一系列神经和精神疾病，最近人们对营养在大脑健康中的作用越来越感兴趣。维生素和矿物质，也被称为微量营养素，是对包括营养代谢、免疫监测、细胞发育、神经传递以及抗氧化和抗炎特性等功能不可或缺的元素。在这篇综述中，我们概述了一些最常见的维生素和矿物质，并讨论了当前研究揭示的这些必需微量营养素与认知表现或阿尔茨海默病之间的联系。
