Bartali B, Devore E, Grodstein F, Kang J H
B. Bartali, New England Research Institutes, Epidemiology, 9 Galen St., Watertown, MA, Email:
J Nutr Health Aging. 2014 Apr;18(4):400-6. doi: 10.1007/s12603-013-0409-9.
Vitamin D may play a role in preserving cognitive function. However, there is a paucity of prospective studies on the relationship between vitamin D and cognition with aging. The aim of this study was to examine the association between plasma levels of vitamin D and subsequent cognitive function.
This is a prospective study including 1,185 women aged 60-70 years from the Nurses' Health Study, who had plasma 25-hydroxy-vitamin D levels measured in 1989-1990 and completed an initial Telephone Interview of Cognitive Status approximately 9 years later. Subsequently, three follow-up cognitive assessments were conducted at 1.5-2.0 years intervals. We used multivariable-adjusted linear regression to model initial cognitive function, and mixed linear regression to model change in cognitive function over time.
Lower vitamin D levels were associated with significantly worse cognitive function 9 years later. For example, the mean global composite score averaging all the cognitive tests was 0.20 lower (95% Confidence Interval (CI):-0.33,-0.08; p-trend=0.009) in women in the lowest quintile (median=14.1 ng/mL) compared with women in the highest quintile of vitamin D (median=38.4 ng/mL). The observed differences were equivalent to the effect estimates we found for women who were approximately 4-6 years apart in age. However, vitamin D levels were not significantly associated with subsequent cognitive decline during 6 years of follow-up.
Higher levels of plasma vitamin D in women aged 60-70 years were associated with better cognitive function about a decade later but were not associated with cognitive decline during 6 years of follow-up.
维生素D可能在维持认知功能方面发挥作用。然而，关于维生素D与衰老过程中认知功能之间关系的前瞻性研究较少。本研究的目的是探讨血浆维生素D水平与后续认知功能之间的关联。
这是一项前瞻性研究，纳入了来自护士健康研究的1185名60 - 70岁女性，她们于1989 - 1990年测量了血浆25 - 羟基维生素D水平，并在大约9年后完成了初次认知状态电话访谈。随后，每隔1.5 - 2.0年进行三次随访认知评估。我们使用多变量调整线性回归来模拟初始认知功能，使用混合线性回归来模拟认知功能随时间的变化。
较低的维生素D水平与9年后显著较差的认知功能相关。例如，在维生素D水平最低五分位数组（中位数 = 14.1 ng/mL）的女性中，所有认知测试的平均总体综合得分比维生素D水平最高五分位数组（中位数 = 38.4 ng/mL）的女性低0.20（95%置信区间(CI)：-0.33，-0.08；p趋势 = 0.009）。观察到的差异相当于我们在年龄相差约4 - 6岁的女性中发现的效应估计值。然而，在6年的随访期间，维生素D水平与随后的认知衰退没有显著关联。
60 - 70岁女性中较高的血浆维生素D水平与大约十年后的较好认知功能相关，但与随访6年期间的认知衰退无关。
