Barsottini Orlando Graziani Povoas, Albuquerque Marcus Vinicius Cristino de, Braga-Neto Pedro, Pedroso José Luiz
Departamento de Neurologia e Neurocirurgia, Unidade Ataxia, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil.
Arq Neuropsiquiatr. 2014 Mar;72(3):232-40. doi: 10.1590/0004-282x20130242.
Patients with adult onset non-familial progressive ataxia are classified in sporadic ataxia group. There are several disease categories that may manifest with sporadic ataxia: toxic causes, immune-mediated ataxias, vitamin deficiency, infectious diseases, degenerative disorders and even genetic conditions. Considering heterogeneity in the clinical spectrum of sporadic ataxias, the correct diagnosis remains a clinical challenge. In this review, the different disease categories that lead to sporadic ataxia with adult onset are discussed with special emphasis on their clinical and neuroimaging features, and diagnostic criteria.
成年起病的非家族性进行性共济失调患者被归类于散发性共济失调组。有几种疾病类别可能表现为散发性共济失调：中毒原因、免疫介导的共济失调、维生素缺乏、传染病、退行性疾病，甚至是遗传疾病。考虑到散发性共济失调临床谱的异质性，正确诊断仍然是一项临床挑战。在本综述中，将讨论导致成年起病的散发性共济失调的不同疾病类别，特别强调其临床和神经影像学特征以及诊断标准。
