Morstyn G, Campbell L, Dührsen U, Souza L M, Alton N K, Villeval J L, Nicola N A, Boyd A W, Kannourakis G, Cebon J
Clinical Research Programme, Melbourne Tumour Biology Branch, Ludwig Institute for Cancer Research, Australia.
Behring Inst Mitt. 1988 Aug(83):234-9.
Bacterially synthesised human granulocyte colony-stimulating factor (G-CSF) was administered to patients with advanced cancer. The immediate effect of G-CSF was a fall in the level of circulating neutrophils followed by a rise after 4 hours that was sustained during G-CSF administration. The rise in neutrophil level was less in patients who had been treated previously with chemotherapy and/or radiotherapy. G-CSF was also administered to patients following melphalan and this resulted in a reduction in the duration of the neutropenia that invariably follows melphalan. G-CSF was well tolerated and did not have to be stopped in any patient.
将细菌合成的人粒细胞集落刺激因子（G-CSF）给予晚期癌症患者。G-CSF的即时效应是循环中性粒细胞水平下降，4小时后上升，并在G-CSF给药期间持续。先前接受过化疗和/或放疗的患者中性粒细胞水平的上升幅度较小。在马法兰治疗后也给患者使用G-CSF，这导致马法兰治疗后必然出现的中性粒细胞减少症的持续时间缩短。G-CSF耐受性良好，没有任何患者必须停药。
