肌肉脂肪 MRI：1.5 特斯拉和 3.0 特斯拉与组织学比较。
Muscle-fat MRI: 1.5 Tesla and 3.0 Tesla versus histology.
机构信息
Northwestern University Interdepartmental Neuroscience Program, Chicago, Illinois, USA.
出版信息
Muscle Nerve. 2014 Aug;50(2):170-6. doi: 10.1002/mus.24255. Epub 2014 Jul 14.
Abstract
INTRODUCTION
We evaluated muscle/fat fraction (MFF) accuracy and reliability measured with an MR imaging technique at 1.5 Tesla (T) and 3.0T scanner strengths, using biopsy as reference.
METHODS
MRI was performed on muscle samples from pig and rabbit species (n = 8) at 1.5T and 3.0T. A chemical shift based 2-point Dixon method was used, collecting in-phase and out-of-phase data for fat/water of muscle samples. Values were compared with MFFs calculated from histology.
RESULTS
No significant difference was found between 1.5T and 3.0T (P values = 0.41-0.96), or between histology and imaging (P = 0.83) for any muscle tested.
CONCLUSIONS
RESULTS suggest that a 2-point Dixon fat/water separation MRI technique may provide reliable quantification of MFFs at varying field strengths across different animal species, and consistency was established with biopsy. The results set a foundation for larger scale investigation of quantifying muscle fat in neuromuscular disorders.
摘要
简介
我们评估了使用活检作为参考的 1.5T 和 3.0T 扫描仪强度的磁共振成像技术测量的肌肉/脂肪分数（MFF）的准确性和可靠性。
方法
在 1.5T 和 3.0T 下对猪和兔肌肉样本进行 MRI 检查。使用基于化学位移的 2 点 Dixon 方法，采集肌肉样本的同相和反相数据以获得脂肪/水。将这些值与组织学计算的 MFF 进行比较。
结果
对于任何测试的肌肉，1.5T 和 3.0T 之间（P 值=0.41-0.96）或组织学和影像学之间（P=0.83）均未发现显著差异。
结论
结果表明，2 点 Dixon 脂肪/水分离 MRI 技术可能在不同动物物种的不同场强下可靠地定量 MFF，并与活检建立了一致性。这些结果为在更大范围内研究神经肌肉疾病中肌肉脂肪的定量奠定了基础。
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