Lee Gary, Jordan Caroline, Tiet Pamela, Ruiz Carlos, McCormick Jeff, Phuong Kevin, Hargreaves Brian, Conolly Steven
Berkeley/UCSF Bioengineering Joint Graduate Group, Berkeley, California, USA; Department of Bioengineering, University of California, Berkeley, Berkeley, California, USA.
J Magn Reson Imaging. 2015 Mar;41(3):684-93. doi: 10.1002/jmri.24581. Epub 2014 Feb 14.
To demonstrate improved frequency selective fat suppression in MRI using a magnetic susceptibility matching foam by reducing B0 inhomogeneities induced within the body by air-tissue interfaces.
Flexible pyrolytic graphite (PG) composite foam was tailored to match the magnetic susceptibility of human tissue and was shaped to surround the cervical spine region. Field maps and frequency selective fat suppressed T1 -weighted FLASH images were acquired at 3 Tesla in both phantoms and six healthy necks.
B0 field uniformity was shimmed to a target critical threshold of 1 ppm for fat suppression. The percentage of voxels in the phantom that did not achieve the critical threshold was reduced from 64% without the PG foam to only 1% with the foam. A similar decrease from 16% to 2% was observed in the in vivo region of interest.
PG foam improved B0 field uniformity by moving air-tissue field gradients outside of the neck where they cannot cause MRI artifacts. The PG foams consistently mitigated signal dropout, improved overall SNR, and enabled more robust frequency selective fat suppression.
通过减少气-组织界面在体内引起的B0不均匀性,证明使用磁敏感性匹配泡沫在MRI中改善频率选择性脂肪抑制。
定制柔性热解石墨(PG)复合泡沫以匹配人体组织的磁敏感性,并将其成型为围绕颈椎区域。在3特斯拉下,在体模和六个健康颈部采集了场图和频率选择性脂肪抑制T1加权快速低角度激发(FLASH)图像。
将B0场均匀性匀场到脂肪抑制的目标临界阈值1 ppm。体模中未达到临界阈值的体素百分比从没有PG泡沫时的64%降至有泡沫时的仅1%。在体内感兴趣区域也观察到类似的从16%降至2%的情况。
PG泡沫通过将气-组织场梯度移到颈部之外,使其不会引起MRI伪影,从而改善了B0场均匀性。PG泡沫持续减轻了信号丢失,提高了整体信噪比,并实现了更稳健的频率选择性脂肪抑制。