Institute of Functional Nano & Soft Materials (FUNSOM) & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu, 215123, China.
Adv Mater. 2014 Jun 4;26(21):3433-40. doi: 10.1002/adma.201305256. Epub 2014 Feb 20.
MoS2 nanosheets functionalized with poly-ethylene glycol are for the first time used as a multifunctional drug delivery system with high drug loading capacities. Using doxorubicin as the model drug and taking advantages of the strong near-infrared absorbance of MoS2, combined photothermal and chemotherapy of cancer is realized in animal experiments, achieving excellent synergistic anti-tumor effect upon systemic administration.
首次将聚乙二醇功能化的 MoS2 纳米片用作具有高载药能力的多功能药物输送系统。以阿霉素为模型药物，并利用 MoS2 的强近红外吸收特性，在动物实验中实现了联合光热和化疗的癌症治疗，在全身给药时实现了优异的协同抗肿瘤效果。
