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自体细胞诱导的淋巴细胞转化。十六：I类主要组织相容性复合体抗原离散区域在自体混合淋巴细胞反应中的独特作用。

Lymphocyte transformation induced by autologous cells. XVI: Distinctive role of discrete regions of class I MHC antigens in the autologous mixed leucocyte reaction.

作者信息

Innes J B, Garbrecht F C, Weksler M E, Russo C

机构信息

Department of Medicine, Cornell University Medical College, New York, NY 10021.

出版信息

Clin Exp Immunol. 1989 Feb;75(2):280-5.

PMID:2467773
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1542125/
Abstract

The role of Class I major histocompatibility complex (MHC) molecules in the autologous (AMLR) and allogeneic mixed lymphocyte reactions was investigated by using monoclonal antibodies (MoAb) directed to polymorphic MHC determinants. The AMLR from subjects with the HLA-A2 phenotype was consistently inhibited by the anti-HLA-A2 MoAb, CR11-351, and the inhibition was dose-dependent and complete even at low antibody concentrations. The allogeneic MLR was inhibited by CR11-351 less than 30% when HLA-A2-bearing cells were used either as stimulator or responder cells. Addition of interleukins 1 and/or 2 to the AMLR in the presence of the inhibiting MoAbs did not restore the proliferative response. These studies suggest that Class I MHC polymorphic determinants, or closely related structures, participate in the induction of the AMLR.

摘要

通过使用针对多态性主要组织相容性复合体（MHC）决定簇的单克隆抗体（MoAb），研究了I类主要组织相容性复合体（MHC）分子在自体混合淋巴细胞反应（AMLR）和同种异体混合淋巴细胞反应中的作用。具有HLA - A2表型的受试者的AMLR始终受到抗HLA - A2 MoAb CR11 - 351的抑制，并且这种抑制是剂量依赖性的，即使在低抗体浓度下也是完全抑制。当使用携带HLA - A2的细胞作为刺激细胞或反应细胞时，CR11 - 351对同种异体混合淋巴细胞反应的抑制作用小于30%。在存在抑制性MoAb的情况下，向AMLR中添加白细胞介素1和/或2并不能恢复增殖反应。这些研究表明，I类MHC多态性决定簇或密切相关的结构参与了AMLR的诱导。

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本文引用的文献

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Analysis of the repertoire of anti-HLA antibodies with anti-idiotypes to a murine anti-HLA-A2,A28 monoclonal antibody.对一种鼠抗人白细胞抗原A2、A28单克隆抗体的抗独特型抗人白细胞抗原抗体库的分析。
Hum Immunol. 1984 May;10(1):57-67. doi: 10.1016/0198-8859(84)90085-5.
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Inhibition of interleukin synthesis and T cell proliferation by a monoclonal anti-Ia antibody.
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Lymphocyte transformation induced by autologous cells. XII. Quantitative and qualitative differences between human autologous and allogeneic reactive T lymphocytes.自体细胞诱导的淋巴细胞转化。十二、人自体和同种异体反应性T淋巴细胞之间的定量和定性差异。
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Monoclonal antibody analysis of human T lymphocyte subpopulations exhibiting autologous mixed lymphocyte reaction.对表现出自体混合淋巴细胞反应的人T淋巴细胞亚群的单克隆抗体分析。
Proc Natl Acad Sci U S A. 1981 Aug;78(8):5096-8. doi: 10.1073/pnas.78.8.5096.
5
HLA-DR antigens render resting T cells sensitive to interleukin-2 and induce production of the growth factor in the autologous mixed lymphocyte reaction.HLA - DR抗原使静息T细胞对白介素 - 2敏感，并在自体混合淋巴细胞反应中诱导生长因子的产生。
Cell Immunol. 1981 Sep 1;63(1):143-53. doi: 10.1016/0008-8749(81)90035-6.
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Stimulation of human T lymphocytes by PHA-activated autologous T lymphocytes: analysis of the role of Ia-like antigens with monoclonal antibodies.PHA激活的自体T淋巴细胞对人T淋巴细胞的刺激作用：用单克隆抗体分析Ia样抗原的作用
Immunogenetics. 1981;12(3-4):267-74. doi: 10.1007/BF01561669.
7
Surface molecules involved in self-recognition and T cell activation in the autologous mixed lymphocyte reaction.自体混合淋巴细胞反应中参与自我识别和T细胞活化的表面分子。
J Immunol. 1984 Sep;133(3):1093-100.
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HLA class I specific T lymphocyte clones with dual alloreactive functions.具有双重同种异体反应性功能的HLA I类特异性T淋巴细胞克隆。
Immunogenetics. 1984;19(1):39-51. doi: 10.1007/BF00364474.
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The alpha chain, not the beta chain of HLA-DR antigens participates in activation of T cells in autologous mixed lymphocyte reaction.在自体混合淋巴细胞反应中，HLA - DR抗原的α链而非β链参与T细胞的激活。
Immunogenetics. 1982;15(4):341-56. doi: 10.1007/BF00364258.
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Reactivity patterns with HLA-A2 variants indicate lack of identity between determinants defined by monoclonal antibodies and cytotoxic-T-cell clones.与HLA - A2变体的反应模式表明，单克隆抗体和细胞毒性T细胞克隆所定义的决定簇之间缺乏一致性。
Cell Immunol. 1984 Oct 1;88(1):228-32. doi: 10.1016/0008-8749(84)90068-6.

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