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Protein changes in immunodepleted cerebrospinal fluid from a transgenic mouse model of Alexander disease detected using mass spectrometry.采用质谱法检测免疫耗竭的亚历山大病转基因小鼠模型脑脊髓液中的蛋白质变化。
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The PRoteomics IDEntifications (PRIDE) database and associated tools: status in 2013.PRIDE 数据库及相关工具：2013 年的现状。
Nucleic Acids Res. 2013 Jan;41(Database issue):D1063-9. doi: 10.1093/nar/gks1262. Epub 2012 Nov 29.
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Cerebrospinal fluid proteome of patients with acute Lyme disease.急性莱姆病患者的脑脊液蛋白质组。
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Neurogranin targets calmodulin and lowers the threshold for the induction of long-term potentiation.神经颗粒蛋白靶向钙调蛋白并降低长时程增强诱导的阈值。
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Advancing the sensitivity of selected reaction monitoring-based targeted quantitative proteomics.提高基于选择反应监测的靶向定量蛋白质组学的灵敏度。
Proteomics. 2012 Apr;12(8):1074-92. doi: 10.1002/pmic.201100436.
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Establishing the proteome of normal human cerebrospinal fluid.建立正常人脑脊液的蛋白质组图谱。
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The blood-brain and the blood-cerebrospinal fluid barriers: function and dysfunction.血脑屏障和血脑脊液屏障：功能和功能障碍。
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Mouse-specific tandem IgY7-SuperMix immunoaffinity separations for improved LC-MS/MS coverage of the plasma proteome.用于改善 LC-MS/MS 对血浆蛋白质组覆盖的小鼠特异性串联 IgY7-SuperMix 免疫亲和分离。
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个体小鼠脑脊液蛋白质组的表征

Characterization of individual mouse cerebrospinal fluid proteomes.

作者信息

Smith Jeffrey S, Angel Thomas E, Chavkin Charles, Orton Daniel J, Moore Ronald J, Smith Richard D

机构信息

Department of Pharmacology, University of Washington, Seattle, WA, USA.

出版信息

Proteomics. 2014 May;14(9):1102-6. doi: 10.1002/pmic.201300241. Epub 2014 Mar 20.

DOI:10.1002/pmic.201300241
PMID:24677814
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4044923/
Abstract

Analysis of cerebrospinal fluid (CSF) offers key insight into the status of the CNS. Characterization of murine CSF proteomes can provide a valuable resource for studying CNS injury and disease in animal models. However, the small volume of CSF in mice has thus far limited individual mouse proteome characterization. Through nonterminal CSF extractions in C57Bl/6 mice and high-resolution 2D-LC MS/MS analysis of individual murine samples, we report the most comprehensive proteome characterization of individual murine CSF to date. We identified a total of 566 unique proteins, including 128 proteins from three individual CSF samples that have been previously identified in brain tissue. Our methods and analysis provide a mechanism for individual murine CSF proteome analysis. The data are available in the ProteomeXchange with identifier PXD000248 (http://proteomecentral.proteomexchange.org/dataset/PXD000248).

摘要

脑脊液（CSF）分析为了解中枢神经系统（CNS）的状态提供了关键见解。对小鼠脑脊液蛋白质组进行表征可为在动物模型中研究中枢神经系统损伤和疾病提供宝贵资源。然而，小鼠脑脊液的量较少，这限制了对单个小鼠蛋白质组的表征。通过对C57Bl/6小鼠进行非终末期脑脊液提取，并对单个小鼠样本进行高分辨率二维液相色谱串联质谱（2D-LC MS/MS）分析，我们报告了迄今为止单个小鼠脑脊液最全面的蛋白质组表征。我们总共鉴定出566种独特蛋白质，其中包括来自三个单个脑脊液样本的128种蛋白质，这些蛋白质先前已在脑组织中被鉴定出来。我们的方法和分析为单个小鼠脑脊液蛋白质组分析提供了一种机制。数据可在蛋白质组交换库中获取，标识符为PXD000248（http://proteomecentral.proteomexchange.org/dataset/PXD000248）。