Raghu Jetti, Raghuveer Vasudeva C, Rao Mallikarjuna C, Somayaji Nagabhooshana S, Babu Prakash B
Department of Anatomy, Melaka Manipal Medical College, Manipal University, Manipal, Karnataka, India.
Department of Pathology, Yenepoya Medical College, Yenepoya University, Mangalore, Karnataka, India.
Interdiscip Toxicol. 2013 Dec;6(4):217-21. doi: 10.2478/intox-2013-0032.
Chronic exposure to fluoride causes dental and skeletal fluorosis. Fluoride exposure is also detrimental to soft tissues and organs. The present study aimed at evaluation of the effect of Ginkgo biloba and ascorbic acid on learning and memory deficits caused by fluoride exposure. Male Wistar rats were divided into five groups (n=6). Group 1 control. Groups 2 to 5 received 100 ppm of sodium fluoride over 30 days. Groups 3, 4 and 5 were further treated for 15 days receiving respectively 1% gum acacia solution, 100 mg/kg body weight ascorbic acid, and 100mg/kg body weight Ginkgo biloba extract. After 45 days, all animals were subjected to behavioural tests. The results showed that fluoride affected learning and memory. Fluoride causes oxidative stress and neurodegeneration, thereby affecting learning and memory. Ascorbic acid and Ginkgo biloba were found to augment the reversal of learning and memory deficits caused by fluoride ingestion.
长期接触氟化物会导致牙齿和骨骼氟中毒。氟化物暴露对软组织和器官也有害。本研究旨在评估银杏和抗坏血酸对氟化物暴露引起的学习和记忆缺陷的影响。雄性Wistar大鼠分为五组（n = 6）。第1组为对照组。第2至5组在30天内接受100 ppm的氟化钠。第3、4和5组在接下来的15天内分别接受1%阿拉伯胶溶液、100 mg/kg体重的抗坏血酸和100 mg/kg体重的银杏叶提取物治疗。45天后，对所有动物进行行为测试。结果表明，氟化物会影响学习和记忆。氟化物会引起氧化应激和神经退行性变，从而影响学习和记忆。研究发现，抗坏血酸和银杏叶能够增强因摄入氟化物而导致的学习和记忆缺陷的逆转。
