Vaghef Ladan, Bafandeh Gharamaleki Hassan
Department of Psychology, Faculty of Education & Psychology, Azarbaijan Shahid Madani University, Tabriz, Iran.
Int J Angiol. 2017 Sep;26(3):158-164. doi: 10.1055/s-0036-1588024. Epub 2016 Oct 12.
Either exercise or Ginkgo biloba is reported to improve cognitive functioning. The aim of this study is to compare the protective effects of forced exercise and Ginkgo biloba on oxidative stress as well as memory impairments induced by transient cerebral ischemia. Adult male Wistar rats were treated with treadmill running or Ginkgo biloba extract for 2 weeks before cerebral ischemia. Memory was assessed using a Morris water maze (MWM) task. At the end of the behavioral testing, oxidative stress biomarkers were evaluated in the hippocampus tissue. As expected, the cerebral ischemia induced memory impairment in the MWM task, and oxidative stress in the hippocampus. These effects were significantly prevented by treadmill running. Indeed, it ameliorated oxidative stress and memory deficits induced by ischemia. In contrast, Ginkgo biloba was not as effective as exercise in preventing ischemia-induced memory impairments. The results confirmed the neuroprotective effects of treadmill running on hippocampus-dependent memory.
据报道，运动或银杏叶都能改善认知功能。本研究的目的是比较强迫运动和银杏叶对短暂性脑缺血诱导的氧化应激以及记忆损伤的保护作用。成年雄性Wistar大鼠在脑缺血前2周接受跑步机跑步或银杏叶提取物治疗。使用莫里斯水迷宫（MWM）任务评估记忆。在行为测试结束时，评估海马组织中的氧化应激生物标志物。正如预期的那样，脑缺血在MWM任务中诱导了记忆损伤，并在海马中诱导了氧化应激。跑步机跑步显著预防了这些影响。事实上，它改善了缺血诱导的氧化应激和记忆缺陷。相比之下，银杏叶在预防缺血诱导的记忆损伤方面不如运动有效。结果证实了跑步机跑步对海马依赖性记忆的神经保护作用。
