Department of Zoology, Bangalore University, Bangalore, 560 056, India.
Biol Trace Elem Res. 2012 Dec;150(1-3):306-13. doi: 10.1007/s12011-012-9489-3. Epub 2012 Aug 25.
In previous studies, we investigated a link between high fluoride exposure and functional IQ deficits in rats. This study is an extension conducted to explore the combined influence of physical exercise and temperature stress on the learning ability and memory in rats and to assess whether any positive modulation could be attenuated due to exercise regimen subjected to F-toxicated animals at different temperatures. Accumulation of ingested fluoride resulted significant inhibition in acetylcholinesterase activity (P < 0.05), plasma cortisol levels (P < 0.05), and impaired the acquisition, performance, latency time, and retention in fluoride-exposed animals. Fluoride-toxicated rats took more number of sessions during the learning phase [F (5, 35) = 19.065; P < 0.05] and post hoc analysis on the number of correct choices revealed that there was a significant effect of treatments [F (5, 30) = 15.763; P < 0.05]; sessions [F (8, 240) = 58.698; P < 0.05]; and also significant difference in the interactions [F (40, 240) = 1.583; P < 0.05]. The latency data also revealed a significant difference between groups [F (5, 30) = 28.085; P < 0.05]; time = [F (8, 240) = 136.314; P < 0.05]; and there was a significant difference in the interactions [F (40, 240) = 2.090; P < 0.05]. In order to ascertain if interdependence between fluoride concentrations and the foregoing free radical parameters, respective correlation coefficients were calculated and results clearly emphasize the positive role of exercise in the promotion of cognitive functions by decreasing fluoride levels in rat hippocampus. A significant recovery in cognitive function was noticed in all the exercised animals due to reduced burden of brain oxidative stress. In comparison to exercise regimens performed at different temperatures, high (35 °C) and low temperatures (20 °C) led to a slower acquisition and poor retention of the task when compared to thermo neutral temperatures (25 and 30 °C). Thus exercise up-regulate antioxidant defenses and promote learning abilities in fluorotic population.
在之前的研究中，我们研究了高氟暴露与大鼠功能性智商缺陷之间的联系。本研究是一项扩展研究，旨在探索体育锻炼和温度应激对大鼠学习能力和记忆力的综合影响，并评估由于氟中毒动物在不同温度下的运动方案，任何可能的积极调节是否会减弱。摄入的氟化物的积累导致乙酰胆碱酯酶活性显著抑制（P<0.05），血浆皮质醇水平（P<0.05），并损害氟暴露动物的获得、表现、潜伏期和保留。氟中毒大鼠在学习阶段需要更多的次数[F（5，35）=19.065；P<0.05]，并且在正确选择的次数上的事后分析表明，处理有显著影响[F（5，30）=15.763；P<0.05]；课程[F（8，240）=58.698；P<0.05]；以及相互作用也有显著差异[F（40，240）=1.583；P<0.05]。潜伏期数据也显示组间有显著差异[F（5，30）=28.085；P<0.05]；时间[F（8，240）=136.314；P<0.05]；相互作用也有显著差异[F（40，240）=2.090；P<0.05]。为了确定氟浓度与上述自由基参数之间的相互依赖性，计算了相应的相关系数，结果清楚地强调了运动在通过降低大鼠海马体中的氟水平来促进认知功能方面的积极作用。由于大脑氧化应激负担减轻，所有运动动物的认知功能都得到了显著恢复。与在不同温度下进行的运动方案相比，高温（35°C）和低温（20°C）导致与热中性温度（25 和 30°C）相比，任务的获得和保留较差。因此，运动上调抗氧化防御机制并促进氟中毒人群的学习能力。
