Head of Diabetes Department, IDF President, Rc: 425201/734, Vel'komoravská 2, Trencin, SK 91101, Slovak Republic.
Eur J Med Res. 2014 Mar 28;19(1):16. doi: 10.1186/2047-783X-19-16.
Extracts from the bark of Hintonia latiflora are used as dietetic measures to support the regulation of glucose metabolism and the stabilization of blood glucose values.
A dry concentrated extract from the bark of Hintonia latiflora in capsule form was tested in an open, prospective clinical study in 41 dietetically stabilized subjects with type 2 diabetes. The effects on parameters of blood glucose control were documented over a period of six months.
Fasting and postprandial glucose and the HbA1c value declined significantly. In the case of HbA1c, this meant a reduction of the absolute value from 7.49 ± 0.72% to 6.82 ± 0.67% (from 58.4 to 51.0 mmol/mol Hb; intention to treat (ITT) population). Furthermore, cholesterol and triglycerides were slightly reduced and no negative effect on other laboratory parameters and no change of the liver values were observed. Tolerance was very good. In particular, no side effects and no hypoglycemic episodes or worsening of diabetic symptoms occurred.
The study confirms the positive effect of extracts from the bark of Hintonia latiflora on blood glucose values suggesting a potential benefit in the management of glucose metabolism in cases of type 2 diabetes.
Reg.-No. ISRCTN83308122.
Hintonia latiflora 的树皮提取物被用作饮食措施，以支持葡萄糖代谢的调节和稳定血糖值。
在一项 41 名饮食稳定的 2 型糖尿病患者的开放性、前瞻性临床研究中，对 Hintonia latiflora 树皮的干浓缩提取物进行了胶囊形式的测试。记录了六个月内血糖控制参数的变化。
空腹和餐后血糖以及 HbA1c 值显著下降。就 HbA1c 而言，这意味着绝对数值从 7.49±0.72%降至 6.82±0.67%（从 58.4 降至 51.0mmol/mol Hb；意向治疗人群）。此外，胆固醇和甘油三酯略有降低，其他实验室参数没有受到负面影响，肝脏值也没有变化。耐受性非常好。特别是，没有观察到副作用、低血糖发作或糖尿病症状恶化。
该研究证实了 Hintonia latiflora 树皮提取物对血糖值的积极影响，表明其在 2 型糖尿病葡萄糖代谢管理中具有潜在益处。
注册号 ISRCTN83308122。
