de Faria Poloni Joice, Chapola Henrique, Feltes Bruno César, Bonatto Diego
Centro de Biotecnologia da Universidade Federal do Rio Grande do Sul, Departamento de Biologia Molecular e Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Biol Cell. 2014 Jun;106(6):167-81. doi: 10.1111/boc.201400008. Epub 2014 Apr 28.
The heart is the first organ in the embryo to form. Its structural and functional complexity is the result of a thorough developmental program, where sphingolipids play an important role in cardiogenesis, heart maturation, angiogenesis, the regulation of vascular tone and vessel permeability. Sphingolipids are necessary for signal transduction and membrane microdomain formation. In addition, recent evidence suggests that sphingolipid metabolism is directly interconnected to the modulation of oxidative stress. However, cardiovascular development is highly sensitive to excessive reactive species production, and disturbances in sphingolipid metabolism can lead to abnormal development and cardiac disease. Therefore, in this review, we address the molecular link between sphingolipids and oxidative stress, connecting these pathways to cardiovascular development and cardiovascular disease.
心脏是胚胎中最先形成的器官。其结构和功能的复杂性是一个全面发育程序的结果，在这个程序中，鞘脂在心脏发生、心脏成熟、血管生成、血管张力调节和血管通透性方面发挥着重要作用。鞘脂对于信号转导和膜微结构域的形成是必需的。此外，最近的证据表明鞘脂代谢与氧化应激的调节直接相关。然而，心血管发育对过量活性物质的产生高度敏感，鞘脂代谢紊乱会导致发育异常和心脏病。因此，在本综述中，我们探讨了鞘脂与氧化应激之间的分子联系，将这些途径与心血管发育和心血管疾病联系起来。
