生物活性脂质信号在心血管疾病、发育和再生中的作用。
Bioactive Lipid Signaling in Cardiovascular Disease, Development, and Regeneration.
机构信息
Regenerative Biology and Cell Reprogramming Laboratory, Institute for Quantitative Health Science and Engineering (IQ), Michigan State University, East Lansing, MI 48824, USA.
Department of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI 48824, USA.
出版信息
Cells. 2020 Jun 3;9(6):1391. doi: 10.3390/cells9061391.
Cardiovascular disease (CVD) remains a leading cause of death globally. Understanding and characterizing the biochemical context of the cardiovascular system in health and disease is a necessary preliminary step for developing novel therapeutic strategies aimed at restoring cardiovascular function. Bioactive lipids are a class of dietary-dependent, chemically heterogeneous lipids with potent biological signaling functions. They have been intensively studied for their roles in immunity, inflammation, and reproduction, among others. Recent advances in liquid chromatography-mass spectrometry techniques have revealed a staggering number of novel bioactive lipids, most of them unknown or very poorly characterized in a biological context. Some of these new bioactive lipids play important roles in cardiovascular biology, including development, inflammation, regeneration, stem cell differentiation, and regulation of cell proliferation. Identifying the lipid signaling pathways underlying these effects and uncovering their novel biological functions could pave the way for new therapeutic strategies aimed at CVD and cardiovascular regeneration.
心血管疾病（CVD）仍然是全球主要的死亡原因。了解和描述心血管系统在健康和疾病中的生化背景，是开发旨在恢复心血管功能的新型治疗策略的必要前提。生物活性脂质是一类饮食依赖性、化学异质的脂质，具有强大的生物学信号功能。它们在免疫、炎症和生殖等方面的作用已得到深入研究。液相色谱-质谱技术的最新进展揭示了大量新型生物活性脂质，其中大多数在生物学背景下是未知的或知之甚少的。其中一些新的生物活性脂质在心血管生物学中发挥着重要作用，包括发育、炎症、再生、干细胞分化和细胞增殖的调节。确定这些作用背后的脂质信号通路，并揭示其新的生物学功能，可能为针对 CVD 和心血管再生的新治疗策略铺平道路。
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