Wang Jun, Han Na, Wang Yao, Wang Yichun, Liu Zhihui, Wang Yu, Yin Jun
a Development and Utilization Key Laboratory of Northeast Plant Materials , School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang 110016 , P.R. China.
Nat Prod Res. 2014;28(16):1306-9. doi: 10.1080/14786419.2014.900618. Epub 2014 Mar 31.
Three alkaloids, (3-chloro-2-hydroxypropyl) trimethylammonium chloride (1), p-(acetylamino)-phenol (2) and 4,4'-diacetamidodiphenyl ether (3), were isolated from Reineckia carnea herba. Their structures were determined by detailed analysis of their 1D and 2D NMR spectra and MS. Compounds 1 and 3 were new natural products. Compound 2 was isolated for the first time from the Reineckia genus. Compound 1 displayed significant in vivo antitussive and expectorant activities.
从吉祥草全草中分离得到三种生物碱，即氯化（3 - 氯 - 2 - 羟丙基）三甲基铵（1）、对（乙酰氨基）苯酚（2）和4,4'-二乙酰氨基二苯醚（3）。通过对其一维和二维核磁共振谱以及质谱的详细分析确定了它们的结构。化合物1和3是新的天然产物。化合物2首次从吉祥草属植物中分离得到。化合物1在体内显示出显著的镇咳和祛痰活性。
