Bora Rajesh O, Dar Bashir, Pradhan Vidya, Farooqui Mazahar
Post Graduate and Research centre, Maulana Azad College, Aurangabad, and Indian Institute of Integrative Medicine Jammu 180001.
Mini Rev Med Chem. 2014 Apr;14(4):355-69. doi: 10.2174/1389557514666140329200745.
In the present article synthesis and medicinal applications of [1, 2, 4] oxadiazoles are reviewed. The oxadiazoles have a wide range of applications such as Antitussive, Anti-inflammatory, Anaesthetic, Vasodilator, anthelmintic, antiallergic, antiplatelet effects in vitro, antithrombotic properties in vivo, etc. Many researchers have synthesized novel heterocyclic compounds containing oxadiazoles with the concept of bioisosterism.
在本文中，对[1, 2, 4]恶二唑的合成及其医学应用进行了综述。恶二唑具有广泛的应用，如镇咳、抗炎、麻醉、血管舒张、驱虫、抗过敏、体外抗血小板作用、体内抗血栓形成特性等。许多研究人员基于生物电子等排体的概念合成了含恶二唑的新型杂环化合物。
