Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard (Deemed to be University), Hamdard Nagar, New Delhi-110 062, India.
Mini Rev Med Chem. 2018;18(18):1536-1547. doi: 10.2174/1389557518666180524112050.
1,2,4-Oxadiazole is one of the important heterocycles used by medicinal chemists in designing a new therapeutic molecule. The compounds containing this nucleus are reported to have a wide range of pharmaceutical and biological applications including anti-inflammatory and analgesic activities. The fused and pendent 1,2,4-oxadiazole moiety has been traced in a number of well established, commercially available drugs. This review article provides an up to date information about techniques adopted for the synthesis of 1,2,4-oxadiazoles, and their therapeutic importance as anti-inflammatory and analgesic agents.
1,2,4-恶二唑是医药化学家在设计新治疗分子时使用的重要杂环之一。含有该核的化合物据报道具有广泛的药物和生物应用，包括抗炎和镇痛活性。许多已确立的、市售的药物中都存在融合和悬垂的 1,2,4-恶二唑部分。这篇综述文章提供了有关合成 1,2,4-恶二唑的技术以及它们作为抗炎和镇痛剂的治疗重要性的最新信息。
