L. M. College of Pharmacy, Navrangpura, Ahmedabad, Gujarat, 380 009, India.
Mol Divers. 2022 Oct;26(5):2967-2980. doi: 10.1007/s11030-021-10375-4. Epub 2022 Jan 5.
Most of the currently marketed drugs consist of heterocyclic scaffolds containing nitrogen and or oxygen as heteroatoms in their structures. Several research groups have synthesized diversely substituted 1,2,4-oxadiazoles as anti-infective agents having anti-bacterial, anti-viral, anti-leishmanial, etc. activities. For the first time, the present review article will provide the coverage of synthetic account of 1,2,4-oxadiazoles as anti-infective agents along with their potential for SAR, activity potential, promising target for mode of action. The efforts have been made to provide the chemical intuitions to the reader to design new chemical entity with potential of anti-infective activity. This review will mark the impact as the valuable, comprehensive and pioneered work along with the library of synthetic strategies for the organic and medicinal chemists for further refinement of 1,2,4-oxadiazole as anti-infective agents.
目前市场上销售的大多数药物都含有杂环支架，其结构中含有氮和/或氧作为杂原子。一些研究小组已经合成了多种取代的 1,2,4-恶二唑作为具有抗细菌、抗病毒、抗利什曼原虫等活性的抗感染药物。本文首次综述了 1,2,4-恶二唑作为抗感染药物的合成研究进展，以及它们的构效关系、活性潜力、有希望的作用机制靶点。本文旨在为读者提供化学直觉，以设计具有抗感染活性的新化学实体。这项研究具有重要意义，是一项全面而开创性的工作，为有机和药物化学家提供了 1,2,4-恶二唑作为抗感染药物的合成策略库，为进一步改进提供了支持。
