Department of Pediatric Nephrology, Medical University of Bialystok , Bialystok , Poland.
Biomarkers. 2014 May;19(3):231-5. doi: 10.3109/1354750X.2014.899393. Epub 2014 Mar 28.
The aim of this study was to investigate if Symmetric Dimethylarginine (SDMA) is a sensitive biomarker of renal function and may predict subclinical kidney injury in low birth weight (LBW) children.
We studied 68 LBW children and 20 children as reference group. An enzyme-linked immunosorbent assay was used to measure serum SDMA and Cystatin C (Cys C).
SDMA levels were higher in study groups compared to reference groups. There was a strong correlation between SDMA and Cys C, also SDMA negatively correlated with eGFR.
Elevated SDMA concentration may play an important role in pathogenesis of chronic kidney disease.
本研究旨在探讨对称性二甲基精氨酸（SDMA）是否为肾功能的敏感生物标志物，并可预测低出生体重（LBW）儿童的亚临床肾脏损伤。
我们研究了 68 名 LBW 儿童和 20 名儿童作为参考组。采用酶联免疫吸附试验（ELISA）法检测血清 SDMA 和胱抑素 C（Cys C）。
与对照组相比，研究组的 SDMA 水平更高。SDMA 与 Cys C 之间存在强相关性，SDMA 与 eGFR 呈负相关。
SDMA 浓度升高可能在慢性肾脏病的发病机制中起重要作用。
