Schneeberger Andres R, Muenzenmaier Kristina, Castille Dorothy, Battaglia Joseph, Link Bruce
a Psychiatric Outpatient Department , Psychiatric Services Grisons , St. Moritz , Switzerland.
J Trauma Dissociation. 2014;15(4):494-511. doi: 10.1080/15299732.2014.903550.
Stressful childhood experiences (SCE) are associated with a variety of health and social problems. In people with severe mental illness (SMI) traumatic childhood experiences have been linked to more severe and treatment refractory forms of psychiatric symptoms, including psychotic symptoms. This study evaluates the use of psychotropic medication groups in a population of people with SMI and SCE, testing the association between SCE and prescription medication in an SMI population. A sample of 183 participants with SMI was divided into 2 exposure groups: high SCE (4 to 7 categories of SCE) and low SCE (0 to 3 categories of SCE). Both groups were compared in regard to prescribed dosing of psychotropic medications (antipsychotics, mood stabilizers, antidepressants, and anxiolytics/hypnotics). Participants who endorsed high SCE received higher doses of antipsychotic medications and mood stabilizers than those with low exposure. The results demonstrate that people with higher SCE categories received a higher dosing of psychotropic medication, specifically antipsychotic medication and mood stabilizers.
童年期应激经历(SCE)与多种健康和社会问题相关。在患有严重精神疾病(SMI)的人群中,童年期创伤经历与更严重且难治的精神症状形式有关,包括精神病性症状。本研究评估了在患有SMI和SCE的人群中精神药物组的使用情况,测试了SCE与SMI人群中处方药之间的关联。183名患有SMI的参与者样本被分为2个暴露组:高SCE组(4至7类SCE)和低SCE组(0至3类SCE)。比较了两组在精神药物(抗精神病药、心境稳定剂、抗抑郁药和抗焦虑药/催眠药)处方剂量方面的情况。认可高SCE的参与者比低暴露者接受了更高剂量的抗精神病药物和心境稳定剂。结果表明,SCE类别较高的人接受了更高剂量的精神药物,特别是抗精神病药物和心境稳定剂。