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2014年的临床营养不良;发病机制、早期诊断及后果;营养不良与营养障碍

Clinical undernutrition in 2014; pathogenesis, early diagnosis and consequences; undernutrition and trophopathy.

作者信息

de Ulíbarri Pérez José Ignacio

机构信息

CONUT® Project. Spain..

出版信息

Nutr Hosp. 2014 Jan 13;29(4):785-96. doi: 10.3305/nh.2014.29.4.7272.

Abstract

The last ten years have allowed me to mature some concepts and criteria in relation to malnutrition in the clinical practice. A lot of us have devoted all our efforts in an attempt to take it under control. The results, however, have shown to be insufficient in the clinical practice, because Hospital Undernutrition still persists in our hospitals and in fact, its prevalence is growing due to an ageing population. I think it is necessary to insist in renaming it as Clinical Undernutrition because it not only appears in hospital settings but it is present before and persists even after hospitalization; the latter reinforces the condition by forcing a change in the habits of the patient and the consequences of the treatments. I would also like to sustain that the risk is not caused by the undernutrition in itself but rather in the disruption of the nutritional balance which is a consequence of the aforementioned conditions and which is defined in a term: Trophopathy; that is, a disruption in the trophism or in the normal functioning of the nutritional status. This disruption constitutes the core risk that is associated with clinical undernutrition and the physical consequences of it. The disruption occurs internally and it will play havoc on cellular nutrition, tissues and further. It appears simultaneously in the blood, so it should be searched and detected there as it is the closest possible place to its origin. The new therapeutic procedures make it possible to cure some cases that in the past were impossible to treat. However, this also means increased risks and so requires a strict control to achieve the best results. Both illness and its treatment put homeostasis at risk and they will definitely impact the nutritional balance, being the latter the key objective in order to achieve or restore the healing process and health. Apart from the benefit obtained with the treatment, it is necessary to apply an appropriate nutritional support that will guarantee the least amount of risks which could derive from an imbalanced nutritional status. The use of automated systems to predict and control the risk factors during the clinical phase makes it possible to have a more thorough control of the illness from its origins, allowing an early diagnosis and treatment of it.

摘要

在过去十年里,我得以在临床实践中完善了一些关于营养不良的概念和标准。我们很多人都全力以赴试图控制它。然而,结果表明在临床实践中这些努力并不够,因为医院营养不良在我们的医院中仍然存在,事实上,由于人口老龄化,其患病率还在上升。我认为有必要坚持将其重新命名为临床营养不良,因为它不仅出现在医院环境中,在住院前就已存在,甚至在出院后仍持续存在;后者通过迫使患者改变习惯以及治疗的后果,进一步加重了这种状况。我还想强调,风险并非由营养不良本身造成,而是由营养平衡的失调导致,这种失调是上述状况的结果,可用一个术语来定义:营养病;也就是说,营养状态的营养作用或正常功能受到破坏。这种失调构成了与临床营养不良及其身体后果相关的核心风险。这种失调在体内发生,会对细胞营养、组织等造成严重破坏。它同时也出现在血液中,所以应该在血液中进行查找和检测,因为血液是离其源头最近的地方。新的治疗方法使一些过去无法治疗的病例得以治愈。然而,这也意味着风险增加,因此需要严格控制以取得最佳效果。疾病及其治疗都会使体内平衡面临风险,肯定会影响营养平衡,而营养平衡是实现或恢复愈合过程及健康的关键目标。除了治疗带来的益处外,有必要提供适当的营养支持,以确保将营养状态失衡可能产生的风险降至最低。在临床阶段使用自动化系统来预测和控制风险因素,能够从源头对疾病进行更全面的控制,实现早期诊断和治疗。

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