INSERM, CIE3, Saint-Etienne, France; Département de Médecine Générale, Université Jean Monnet, Saint-Etienne, France; EA3065, Université Jean Monnet, PRES de Lyon, Saint-Etienne, France.
J Thromb Haemost. 2014 Jun;12(6):831-8. doi: 10.1111/jth.12575.
The incidence of superficial vein thrombosis (SVT) in the general adult population remains unknown.
To assess the annual diagnosis rate of symptomatic, objectively confirmed lower limb SVT, associated or not with concomitant deep vein thrombosis and/or symptomatic pulmonary embolism.
METHODS/PATIENTS: We conducted, from November 14, 2011, to November 13, 2012, a multicenter, community-based study in the Saint-Etienne urban area, France, representing a population of 265 687 adult residents (according to the 2009 census). All 248 general practitioners located within the area were asked to refer any patient with clinically suspected lower limb acute SVT to a vascular physician for systematic compression ultrasonography. All 28 vascular physicians located within the area participated in the study. The annual diagnosis rate, with the corresponding 95% confidence interval (CI), was calculated as the number of patients with symptomatic, objectively confirmed SVT divided by the number of person-years at risk defined by population data of the area. All venous thromboembolic events were validated by an independent central adjudication committee.
Overall, 171 patients with symptomatic, confirmed SVT were reported. The annual diagnosis rate was 0.64& (95% CI, 0.55%-0.74&), was higher in women, and increased with advancing age regardless of gender [corrected]. Concomitant deep vein thrombosis (20 proximal) was observed in 42 patients (24.6% [95% CI, 18.3%-31.7%]), and concomitant symptomatic pulmonary embolism was observed in eight patients (4.7% [95% CI, 2.0%-9.0%]).
This first community-based study showed that symptomatic SVT with confirmed diagnosis is a relatively common disease frequently associated with thromboembolic events in the deep venous system.
在普通成年人群中，浅静脉血栓形成（SVT）的发病率尚不清楚。
评估有症状的、经客观证实的下肢 SVT 的年诊断率，包括与深静脉血栓形成和/或有症状的肺栓塞相关或不相关的情况。
方法/患者：我们于 2011 年 11 月 14 日至 2012 年 11 月 13 日进行了一项多中心、基于社区的研究，研究地点在法国圣艾蒂安市区，代表了 265687 名成年居民的人口（根据 2009 年的人口普查）。该地区内的 248 名全科医生被要求将任何有临床疑似下肢急性 SVT 症状的患者转介给血管科医生进行系统的压缩超声检查。该地区内的 28 名血管科医生均参与了该研究。年诊断率（相应的 95%置信区间[CI]）的计算方法为，有症状的、经客观证实的 SVT 患者人数除以该地区人口数据定义的风险人群年数。所有静脉血栓栓塞事件均由一个独立的中央裁决委员会进行验证。
共报告了 171 例有症状、确诊的 SVT 患者。年诊断率为 0.64%（95%CI，0.55%-0.74%），女性较高，且无论性别如何，随年龄增长而增加[校正]。在 42 例患者（24.6%[95%CI，18.3%-31.7%]）中观察到合并近端深静脉血栓形成（20 例），在 8 例患者（4.7%[95%CI，2.0%-9.0%]）中观察到合并有症状的肺栓塞。
这项首次基于社区的研究表明，有症状的、经确诊的 SVT 是一种相对常见的疾病，常与深静脉系统中的血栓栓塞事件相关。
