Department of Surgery, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA.
Surgery, Bioethics and Medical Humanities, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA.
Surg Clin North Am. 2014 Apr;94(2):361-75. doi: 10.1016/j.suc.2014.01.004. Epub 2014 Feb 18.
Our understanding of bile metabolism and the molecular effects of bile acids has expanded in recent years. Bile acids, which are classically recognized for their involvement in dietary lipid absorption, are now known to be involved in many aspects of energy metabolism and disease processes in humans. Cholelithiasis, a consequence of altered bile metabolism, affects a significant number of American adults. An understanding of the disease process, risk factors, and complications of gallbladder disease is necessary for the development of novel targeted treatments and prophylactic therapies against the development of gallstones.
近年来，我们对胆汁代谢和胆汁酸的分子作用的理解已经扩展。胆汁酸经典上被认为参与膳食脂质吸收，现在已知其参与人体许多方面的能量代谢和疾病过程。胆石症是胆汁代谢改变的结果，影响了相当数量的美国成年人。了解疾病过程、风险因素和胆囊疾病的并发症对于开发针对胆结石形成的新型靶向治疗和预防治疗是必要的。
