蛋白质质量控制的差异尺度。

Differential scales of protein quality control.

机构信息

Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.

Department of Cellular and Molecular Pharmacology, California Institute of Quantitative Biology, Center for RNA Systems Biology, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA.

出版信息

Cell. 2014 Mar 27;157(1):52-64. doi: 10.1016/j.cell.2014.03.007.

DOI:10.1016/j.cell.2014.03.007

PMID:24679526

Abstract

Proteins are notorious for their unpleasant behavior-continually at risk of misfolding, collecting damage, aggregating, and causing toxicity and disease. To counter these challenges, cells have evolved elaborate chaperone and quality control networks that can resolve damage at the level of the protein, organelle, cell, or tissue. On the smallest scale, the integrity of individual proteins is monitored during their synthesis. On a larger scale, cells use compartmentalized defenses and networks of communication, capable sometimes of signaling between cells, to respond to changes in the proteome's health. Together, these layered defenses help protect cells from damaged proteins.

摘要

蛋白质的行为令人讨厌，它们一直面临错误折叠、积聚损伤、聚集以及毒性和疾病的风险。为了应对这些挑战，细胞已经进化出了精细的伴侣蛋白和质量控制网络，可以在蛋白质、细胞器、细胞或组织水平上解决损伤。在最小的尺度上，在蛋白质合成过程中会监测单个蛋白质的完整性。在更大的尺度上，细胞利用分隔的防御和通信网络，有时能够在细胞之间发出信号，以响应蛋白质组健康状况的变化。这些分层防御共同帮助细胞免受损伤蛋白的侵害。