Filipek Kamil, Penzo Marianna
Department of Medical and Surgical Sciences, and Center for Applied Biomedical Research, Alma Mater Studiorum University of Bologna, Bologna, Italy.
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Cancer Metastasis Rev. 2024 Dec 2;44(1):13. doi: 10.1007/s10555-024-10234-2.
Gynecologic cancers are a significant cause of morbidity and mortality among women worldwide. Despite advancements in diagnosis and treatment, the molecular mechanisms underlying the development and progression of these cancers remain poorly understood. Recent studies have implicated translational machinery (ribosomal proteins (RPs) and translation factors (TFs)) as potential drivers of oncogenic processes in various cancer types, including gynecologic cancers. RPs are essential components of the ribosome, which is responsible for protein synthesis. In this review paper, we aim to explore the role of translational machinery in gynecologic cancers. Specifically, we will investigate the potential mechanisms by which these components contribute to the oncogenic processes in these cancers and evaluate the feasibility of targeting RPs as a potential therapeutic strategy. By doing so, we hope to provide a broader view of the molecular pathogenesis of gynecologic cancers and highlight their potential as novel therapeutic targets for the management of these challenging diseases.
妇科癌症是全球女性发病和死亡的重要原因。尽管在诊断和治疗方面取得了进展，但这些癌症发生和发展的分子机制仍知之甚少。最近的研究表明，翻译机制（核糖体蛋白（RPs）和翻译因子（TFs））是包括妇科癌症在内的各种癌症类型致癌过程的潜在驱动因素。核糖体蛋白是核糖体的重要组成部分，负责蛋白质合成。在这篇综述文章中，我们旨在探讨翻译机制在妇科癌症中的作用。具体而言，我们将研究这些成分促成这些癌症致癌过程的潜在机制，并评估将核糖体蛋白作为潜在治疗策略的可行性。通过这样做，我们希望提供更广泛的妇科癌症分子发病机制观点，并突出它们作为管理这些具有挑战性疾病的新型治疗靶点的潜力。
