整合生物设计：合成生物学的起源与未来发展方向。
Integrating biological redesign: where synthetic biology came from and where it needs to go.
机构信息
Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA; Howard Hughes Medical Institute, Department of Biomedical Engineering and Center of Synthetic Biology, Boston University, Boston, MA 02115, USA.
出版信息
Cell. 2014 Mar 27;157(1):151-61. doi: 10.1016/j.cell.2014.02.039.
Synthetic biology seeks to extend approaches from engineering and computation to redesign of biology, with goals such as generating new chemicals, improving human health, and addressing environmental issues. Early on, several guiding principles of synthetic biology were articulated, including design according to specification, separation of design from fabrication, use of standardized biological parts and organisms, and abstraction. We review the utility of these principles over the past decade in light of the field's accomplishments in building complex systems based on microbial transcription and metabolism and describe the progress in mammalian cell engineering.
合成生物学旨在将工程和计算方法扩展到生物学的重新设计，其目标包括生成新的化学物质、改善人类健康和解决环境问题。早期，人们提出了合成生物学的几个指导原则，包括根据规范进行设计、设计与制造分离、使用标准化的生物部件和生物体以及抽象化。我们根据基于微生物转录和代谢构建复杂系统的领域成就，回顾了过去十年这些原则的实用性，并描述了哺乳动物细胞工程的进展。
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