新型肿瘤坏死因子-α生成抑制剂vialinin C的结构解析与合成

Structural elucidation and synthesis of vialinin C, a new inhibitor of TNF-α production.

作者信息

Ye Yue Qi, Negishi Chiemi, Hongo Yayoi, Koshino Hiroyuki, Onose Jun-ichi, Abe Naoki, Takahashi Shunya

机构信息

RIKEN, Wako-shi, Saitama 351-0198, Japan; Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan.

Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan.

出版信息

Bioorg Med Chem. 2014 Apr 15;22(8):2442-6. doi: 10.1016/j.bmc.2014.02.058. Epub 2014 Mar 6.

DOI:10.1016/j.bmc.2014.02.058

PMID:24679673

Abstract

A new inhibitor of TNF-α production (IC50=0.89 μM) named vialinin C (1) was isolated from dry fruiting bodies of an edible Chinese mushroom, Thelephora vialis. The structure of 1 was determined by high-resolution MS, NMR spectroscopic analysis, and confirmed by synthesis. Synthesis of ganbajunin B (5) obtained from the same origin was also described.

摘要

从中国一种可食用蘑菇——小孔革菌的干燥子实体中分离出一种名为vialinin C（1）的新型肿瘤坏死因子-α产生抑制剂（IC50 = 0.89 μM）。通过高分辨率质谱、核磁共振光谱分析确定了1的结构，并通过合成进行了确证。还描述了从同一来源获得的干巴菌宁B（5）的合成。