Higa Futoshi, Furugen Makoto, Koide Michio, Karimata Yosuke, Nabeya Daijiro, Iha Yoshikazu, Kinjo Takeshi, Miyagi Kazuya, Haranaga Shusaku, Hokama Akira, Tateyama Masao, Fujita Jiro
Department of Infectious, Respiratory, and Digestive Medicine, Graduate School of Medicine, University of the Ryukyus, 903-0215 Okinawa, Japan.
Department of Infectious, Respiratory, and Digestive Medicine, Graduate School of Medicine, University of the Ryukyus, 903-0215 Okinawa, Japan.
J Infect Chemother. 2014 May;20(5):289-92. doi: 10.1016/j.jiac.2013.10.014. Epub 2013 Dec 11.
High mobility group box 1 (HMGB-1) protein is involved in acute lung injury due to various etiologies. We evaluated HMGB-1 levels in sera and bronchoalveolar fluids in patients with pneumonia caused by Legionella pneumophila. Levels of HMGB-1 in the sera of patients with L. pneumophila pneumonia (32 cases) and control subjects (24 cases) were determined. Serum HMGB-1 levels in Legionella pneumonia were similar to those of the control subjects. No significant correlation between HMGB-1 levels and other biomarkers and the outcome of cases was observed. In contrast, HMGB-1 levels, as well as interferon-γ, in bronchoalveolar (BA) fluids from severe L. pneumophila pneumonia (7 cases) were significantly higher than those in the sera of identical patients. HMGB-1 levels in BA fluids were relatively higher in pneumonia cases with ALI than those without ALI. Our findings suggest that intra-pulmonary HMGB-1 may be involved in the pathophysiology of pneumonia caused by L. pneumophila.
高迁移率族蛋白B1（HMGB-1）参与多种病因所致的急性肺损伤。我们评估了嗜肺军团菌所致肺炎患者血清及支气管肺泡灌洗液中HMGB-1的水平。测定了嗜肺军团菌肺炎患者（32例）及对照者（24例）血清中HMGB-1的水平。嗜肺军团菌肺炎患者血清HMGB-1水平与对照者相似。未观察到HMGB-1水平与其他生物标志物及病例转归之间存在显著相关性。相比之下，重症嗜肺军团菌肺炎患者（7例）支气管肺泡灌洗液中的HMGB-1水平以及干扰素-γ水平显著高于同一患者的血清水平。伴有急性肺损伤（ALI）的肺炎病例支气管肺泡灌洗液中HMGB-1水平相对高于无ALI的病例。我们的研究结果提示，肺内HMGB-1可能参与嗜肺军团菌所致肺炎的病理生理过程。
