Javed Fawad, Ramalingam Sundar, Ahmed Hameeda Bashir, Gupta Bhumija, Sundar Chalini, Qadri Talat, Al-Hezaimi Khalid, Romanos Georgios E
Eng. A. B. Research Chair for Growth Factors and Bone Regeneration, 3D Imaging and Biomechanical Laboratory, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Department of Oral and Maxillofacial Surgery, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
Crit Rev Oncol Hematol. 2014 Aug;91(2):123-9. doi: 10.1016/j.critrevonc.2014.02.007. Epub 2014 Mar 12.
Oral health status is jeopardized in patients with neurofibromatosis (NF) type-1 (NF-1). The aim of the present study was to comprehensively review the oral manifestations in NF-1 patients. PubMed/Medline and Google-Scholar databases were explored using different keywords. Reviews, commentaries, letters to Editor and articles published in languages other than English were excluded.
Neurofibromas of oral and perioral soft tissues with subsequent periodontitis, impacted and supernumerary teeth, enlarged alveolar process with dental spacing, morphological changes in teeth and class III molar relationship have been reported in NF-1 patients. Plexiform neurofibromas were reported both in oral soft tissue, maxilla and mandible with evidence of malignant transformation in some cases. Facial skeletal abnormalities, including enlargement of mandibular foramen, increased dimensions of the coronoid and sigmoid notches and notching of the posterior border of the mandible have also been reported. Association between dental caries and NF-1 remains unclear.
1型神经纤维瘤病（NF-1）患者的口腔健康状况受到威胁。本研究的目的是全面回顾NF-1患者的口腔表现。使用不同关键词检索了PubMed/Medline和谷歌学术数据库。排除综述、评论、致编辑的信以及非英文发表的文章。
NF-1患者中报告了口腔及口周软组织神经纤维瘤伴随后续的牙周炎、阻生牙和多生牙、牙槽突增大伴牙间隙、牙齿形态改变以及Ⅲ类磨牙关系。口腔软组织、上颌骨和下颌骨均有丛状神经纤维瘤的报告，部分病例有恶变证据。还报告了面部骨骼异常，包括下颌孔扩大、冠突和乙状切迹尺寸增加以及下颌骨后缘切迹。龋齿与NF-1之间的关联仍不清楚。
