University of Brescia, Dental Clinic, Brescia, Italy.
Eur J Paediatr Dent. 2011 Dec;12(4):256-60.
The scientific literature is poor of data concerning NF1-related oral manifestations in children. The purpose of this study was to investigate the oral findings in a group of children with NF1.
This study was designed as a clinical research. A total of 50 children affected by NF1 were enrolled. Non-NF1 controls were selected among subjects referred to the Paediatric Dentistry Department of the Dental Clinic at the University of Brescia, Italy. The craniofacial and all the dental examinations were carried out. The following parameters were investigated: dental caries, dental abnormalities, periodontal status, oral and perioral neurofibromas, orthodontic features, mandible and temporomandibular joint abnormalities. Statistics Unpaired Student's t test was calculated for Gaussian distributed variables; Fisher's test for non-Gaussian distributed binomial variables was used. The values inferior to p <0.05 (threshold) were considered significant for the study.
Children with NF1 showed poorer oral hygiene conditions, more frequent Class III dental malocclusions and severe alterations of the mandible and the temporal mandibular joint, if compared with the control group.
NF1 related-oral manifestations are evidenced also during childhood, even if some of the best known, like the neurofibromas, are not yet developed. It is important to keep a long-term follow-up to monitor the possible development of other oral lesions.
有关 NF1 相关口腔表现的科学文献数据匮乏。本研究旨在调查一组 NF1 患儿的口腔发现。
本研究设计为临床研究。共纳入 50 名患有 NF1 的儿童。选择意大利布雷西亚大学牙科诊所儿科牙科就诊的非 NF1 对照者。进行了颅面和所有牙齿检查。研究了以下参数：龋齿、牙齿异常、牙周状况、口腔和口周神经纤维瘤、正畸特征、下颌和颞下颌关节异常。正态分布变量采用未配对学生 t 检验进行统计；非正态分布二项变量采用 Fisher 检验。低于 p<0.05（阈值）的值被认为对研究具有统计学意义。
与对照组相比，NF1 患儿的口腔卫生状况较差，III 类错牙合畸形更为常见，下颌和颞下颌关节严重改变。
即使一些最知名的 NF1 相关口腔表现，如神经纤维瘤尚未出现，在儿童期也已存在。重要的是要进行长期随访，以监测其他口腔病变的可能发展。
