School of Pharmacy, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do, 440-746, South Korea.
Department of Health Administration and Management 1619, Soon Chun Hyang University, 646 Eupnae-ri, Shinchang-myeon, Asan City, Chungnam, 336-745, South Korea.
Epilepsy Res. 2014 Jul;108(5):963-71. doi: 10.1016/j.eplepsyres.2014.02.014. Epub 2014 Mar 12.
This study aimed to measure utilities, which are quantitative terms incorporating preferences, for various health states of epilepsy with partial seizure in the general population in South Korea. It also aimed to find socio-demographic characteristics associated with the utility scores.
Utility scores using Time Trade-Off (TTO), Visual Analog Scale (VAS), and EuroQol five Dimension (EQ-5D) were obtained from 300 people aged 16 and over by face-to-face interviews. We measured utilities for three hypothetical health states of epilepsy for which scenarios were defined based on the frequency of partial seizure: seizure-free, seizure reduction, and withdrawal. We compared utilities with varying seizure frequency using a repeated-measures ANOVA, and analyzed the association between utilities and socio-demographic characteristics using a generalized estimating equation (GEE).
The mean utility scores for withdrawal state, seizure reduction state, and seizure-free state were 0.303, 0.493, and 0.899, respectively, when measured by TTO. VAS yielded the mean utility scores of 0.211, 0.424, and 0.752 for respective health states, and corresponding scores with EQ-5D were 0.261, 0.645, and 0.959. The utility scores for the three health states were statistically different in TTO, VAS, and EQ-5D. The withdrawal state had the lowest utility scores. There were differences in mean utilities for the three health states across the three methods. Utilities by EQ-5D tended to have higher values than those by TTO and VAS. Utilities by VAS had the lowest values. In GEE analysis, the severity of epilepsy and household income were significantly related to utility scores.
The withdrawal state of epilepsy had the lowest utility value and the seizure-free state had the highest by all three techniques of utility measurement used. There were significant differences in utilities between one severity level of epilepsy and another. Utility was associated with household income and the severity of disease. Utility scores for distinct epilepsy states obtained in this study could facilitate health economic analyses of epilepsy treatments and thus help decision making in resource allocation.
本研究旨在衡量韩国普通人群中部分性癫痫发作的各种健康状态的效用，这些效用是包含偏好的定量术语。本研究还旨在发现与效用评分相关的社会人口统计学特征。
通过面对面访谈，从 300 名 16 岁及以上的人群中获得了使用时间权衡（TTO）、视觉模拟量表（VAS）和 EuroQol 五维量表（EQ-5D）的效用评分。我们根据部分性癫痫发作的频率定义了三种假设的癫痫健康状态的场景，并对这些场景进行了测量：无癫痫发作、癫痫发作减少和停药。我们使用重复测量方差分析比较了不同癫痫发作频率的效用，并使用广义估计方程（GEE）分析了效用与社会人口统计学特征之间的关系。
当使用 TTO 测量时，停药状态、癫痫发作减少状态和无癫痫发作状态的平均效用评分分别为 0.303、0.493 和 0.899。VAS 分别产生了 0.211、0.424 和 0.752 的健康状态平均效用评分，而 EQ-5D 的相应评分分别为 0.261、0.645 和 0.959。在 TTO、VAS 和 EQ-5D 中，三种健康状态的效用评分存在统计学差异。停药状态的效用评分最低。在三种方法中，三种健康状态的平均效用评分存在差异。EQ-5D 的效用评分倾向于高于 TTO 和 VAS。VAS 的效用评分最低。在 GEE 分析中，癫痫的严重程度和家庭收入与效用评分显著相关。
在所有三种效用测量技术中，癫痫停药状态的效用值最低，无癫痫发作状态的效用值最高。不同严重程度的癫痫之间的效用存在显著差异。效用与家庭收入和疾病严重程度有关。本研究中获得的不同癫痫状态的效用评分可以促进癫痫治疗的健康经济分析，从而有助于资源分配的决策。
