Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458, USA; Department of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.
Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458, USA; Department of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.
Curr Opin Cell Biol. 2014 Apr;27:102-8. doi: 10.1016/j.ceb.2013.11.010. Epub 2013 Dec 22.
At one time, G protein-coupled receptors were envisioned to simply relay either inhibitory or stimulatory binary signals through engaging particular G proteins. These receptors are now viewed as complex, multidimensional triggers of a variety of potential signaling cascades. This review will showcase current attempts to elucidate biased signaling and functional selectivity in tissues and organs as well as in the whole animal. In addition, it will emphasize the challenges that are inherent in attributing bias in a living system as well as offer opinions as to the manner in which these problems may be approached.
曾经，G 蛋白偶联受体被认为仅仅通过结合特定的 G 蛋白来传递抑制性或刺激性的二元信号。而现在，这些受体被视为复杂的、多维的潜在信号级联反应的触发因素。本综述将展示目前在组织和器官以及整个动物中阐明偏向信号传递和功能选择性的尝试。此外，它还将强调在活系统中归因于偏向性的固有挑战，并就如何解决这些问题提出意见。
