Sixth Department of Radiation Oncology, Shandong Cancer Hospital, Jinan, Shandong Province, China; School of Medicine and Life Sciences, University of Jinan - Shandong Academy of Medical Sciences, Jinan, Shandong Province, China.
Sixth Department of Radiation Oncology, Shandong Cancer Hospital, Jinan, Shandong Province, China; Department of Radiation Oncology, Cancer Hospital, Tianjin Medical University, Tianjin Province, China.
Biochem Biophys Res Commun. 2014 Apr 18;446(4):1197-203. doi: 10.1016/j.bbrc.2014.03.087. Epub 2014 Mar 26.
MicroRNA is a class of small, well-conserved, non-coding RNAs, and could play a potential role as diagnostic and prognostic biomarkers of esophageal cancers. We aimed to review comprehensively the evidence of microRNA as prognostic biomarkers in esophageal cancers.
Studies were identified by searching PubMed, Embase and Web of Science until November 2013. Descriptive characteristics of studies were described and an additional meta-analysis for specific microRNAs which were studied most frequently was performed. Pooled hazard ratios (HRs) and their corresponding 95% confidence intervals (CIs) were calculated. Fixed model or random model method was chosen depending on the heterogeneity among the studies.
Twenty-two studies including a total of 1946 participants were enrolled after a strict filtering and qualifying process. Among 33 prognostic microRNAs identified for esophageal cancer, miR-21 and miR-375 appeared more frequently. The median study size was 70.5 patients (29-249 patients) and the median HR was 3.305 (IQR=1.615-7.31). For the studies evaluating miR-21's association with overall survival (OS), the pooled HR suggested that high level of miR-21 has a negative impact on OS (HR=1.52[1.17-1.98], P=0.001). As for miR-375, the pooled HR for OS (high/low) was 0.53 (95% CI: 0.39-0.73, P<0.001), indicated that low level of miR-375 has a negative impact on OS. These results indicated that microRNAs show promising associations with prognosis in esophageal cancer. Up-regulation of miR-21 and down-regulation of miR-375 can predict unfavourable prognosis in esophageal cancer.
microRNA 是一类小的、高度保守的非编码 RNA，可以作为食管癌的诊断和预后生物标志物发挥潜在作用。我们旨在全面回顾 microRNA 作为食管癌预后生物标志物的证据。
通过搜索 PubMed、Embase 和 Web of Science 数据库，检索截至 2013 年 11 月的研究。描述研究的特征，并对研究最频繁的特定 microRNA 进行额外的荟萃分析。计算汇总危险比（HR）及其相应的 95%置信区间（CI）。根据研究之间的异质性选择固定模型或随机模型方法。
经过严格的筛选和筛选过程，共纳入 22 项研究，共纳入 1946 名参与者。在确定的 33 个与食管癌相关的预后 microRNA 中，miR-21 和 miR-375 更为常见。中位数研究规模为 70.5 例（29-249 例），中位数 HR 为 3.305（IQR=1.615-7.31）。对于评估 miR-21 与总生存（OS）相关性的研究，汇总 HR 表明高水平的 miR-21 对 OS 有负面影响（HR=1.52[1.17-1.98]，P=0.001）。对于 miR-375，OS（高/低）的汇总 HR 为 0.53（95%CI：0.39-0.73，P<0.001），表明低水平的 miR-375 对 OS 有负面影响。这些结果表明 microRNA 与食管癌的预后有很好的相关性。miR-21 的上调和 miR-375 的下调可以预测食管癌的不良预后。
