Department of Nephrology, The Second Hospital of Anhui Medical University, Hefei, China.
Ren Fail. 2020 Nov;42(1):1059-1066. doi: 10.1080/0886022X.2020.1832521.
To systematically evaluate the relationship between the neutrophil-to-lymphocyte ratio (NLR) and the risk of all-cause mortality or cardiovascular events in patients with chronic kidney disease (CKD).
PubMed, Embase, and Web of Science databases were searched for cohort studies that were published since the databases were launched, until 1 April 2020. We selected papers according to specific inclusion and exclusion criteria, extracted data, and evaluated the quality of the citations. Data from eligible studies were used to calculate the combined hazard ratios (HRs) and 95% confidence intervals (CI).
The search identified 1048 potentially eligible records, and 10 studies ( = 1442) were selected. Eight studies reported all-cause mortality, and two studies reported cardiovascular events. The combined HR of all-cause mortality was 1.45 (95% CI 1.20-1.75) and the HR of cardiovascular events was 1.52 (95% CI 1.33-1.72) when NLR was considered as a categorical variable. Similarly, the association between NLR and all-cause mortality was confirmed (HR 1.35; 95% CI 1.23-1.48) when NLR was used as a continuous variable.
NLR is a predictor of all-cause mortality and cardiovascular events in patients with chronic kidney disease.
系统评价中性粒细胞与淋巴细胞比值（NLR）与慢性肾脏病（CKD）患者全因死亡率或心血管事件风险的关系。
检索 PubMed、Embase 和 Web of Science 数据库，纳入自数据库建立至 2020 年 4 月 1 日发表的队列研究。根据特定的纳入和排除标准选择文献、提取数据并评价引用质量。使用合格研究的数据计算合并危险比（HR）和 95%置信区间（CI）。
搜索共确定了 1048 篇潜在合格记录，选择了 10 项研究（n=1442）。8 项研究报告了全因死亡率，2 项研究报告了心血管事件。当 NLR 被视为分类变量时，全因死亡率的合并 HR 为 1.45（95% CI 1.20-1.75），心血管事件的 HR 为 1.52（95% CI 1.33-1.72）。同样，当 NLR 被视为连续变量时，NLR 与全因死亡率之间的关联也得到了证实（HR 1.35；95% CI 1.23-1.48）。
NLR 是慢性肾脏病患者全因死亡率和心血管事件的预测指标。
