Population Studies Division, Environmental Health Science and Research Bureau, Health Canada, 50 Columbine Driveway, Ottawa, Ontario K1A 0K9, Canada.
Population Studies Division, Environmental Health Science and Research Bureau, Health Canada, 50 Columbine Driveway, Ottawa, Ontario K1A 0K9, Canada.
Environ Pollut. 2014 Jun;189:208-14. doi: 10.1016/j.envpol.2014.03.004. Epub 2014 Mar 27.
Studying the physiologic effects of components of fine particulate mass (PM2.5) could contribute to a better understanding of the nature of toxicity of air pollution.
We examined the relation between acute changes in cardiovascular and respiratory function, and PM2.5-associated-metals.
Using generalized linear mixed models, daily changes in ambient PM2.5-associated metals were compared to daily changes in physiologic measures in 59 healthy subjects who spent 5-days near a steel plant and 5-days on a college campus.
Interquartile increases in calcium, cadmium, lead, strontium, tin, vanadium and zinc were associated with statistically significant increases in heart rate of 1-3 beats per minute, increases of 1-3 mmHg in blood pressure and/or lung function decreases of up to 4% for total lung capacity.
Metals contained in PM2.5 were found to be associated with acute changes in cardiovascular and respiratory physiology.
研究细颗粒物（PM2.5）成分的生理效应有助于更好地了解空气污染毒性的本质。
我们研究了心血管和呼吸功能的急性变化与 PM2.5 相关金属之间的关系。
使用广义线性混合模型，将在钢铁厂附近度过 5 天和在大学校园度过 5 天的 59 名健康受试者的环境 PM2.5 相关金属的每日变化与生理指标的每日变化进行比较。
钙、镉、铅、锶、锡、钒和锌的四分位间距增加与心率每分钟增加 1-3 次、血压升高 1-3mmHg 以及肺活量下降高达 4%有关。
PM2.5 中含有的金属与心血管和呼吸生理的急性变化有关。
