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连续与单次坐骨神经阻滞联合连续股神经阻滞用于全膝关节置换术后镇痛:一项前瞻性、随机、双盲研究。

Continuous versus single-injection sciatic nerve block added to continuous femoral nerve block for analgesia after total knee arthroplasty: a prospective, randomized, double-blind study.

机构信息

From the *Department of Anesthesiology, Tokyo Women's Medical University, Tokyo; and †Department of Anesthesiology, Kitano Hospital, Osaka, Japan.

出版信息

Reg Anesth Pain Med. 2014 May-Jun;39(3):225-9. doi: 10.1097/AAP.0000000000000076.

Abstract

BACKGROUND AND OBJECTIVES

The benefit of adding sciatic nerve block (SNB) to femoral nerve block to improve analgesia after total knee arthroplasty (TKA) is uncertain. We hypothesized that the effective duration of single-injection SNB is too short to improve postoperative analgesia and that this contributes to conflicting results on the efficacy of SNB after TKA. We evaluated this hypothesis in a prospective double-blind randomized controlled trial.

METHODS

Sixty patients undergoing TKA were randomly allocated to a continuous SNB group or a single-injection SNB group. All patients received femoral nerve block (0.5% ropivacaine 20 mL) and SNB (0.2% ropivacaine 20 mL) and catheters were inserted into both peripheral nerve block sites before surgery. Both groups received continuous femoral nerve block and patient-controlled intravenous analgesia with morphine. Continuous SNB (0.2% ropivacaine 5 mL/h; continuous SNB group) or sham continuous SNB (0.9% normal saline 5 mL/h; single-injection SNB group) was provided after surgery. The primary outcome was total morphine consumption for 48 hours after surgery.

RESULTS

Total morphine consumption in the 48-hour period after surgery was significantly lower in the continuous SNB group compared with the single-injection SNB group [4.9 (5.9) vs 9.7 (9.5) mg, P = 0.002]. Visual analog scale pain scores at rest were also significantly lower in the continuous SNB group (P = 0.035).

CONCLUSIONS

The combination of continuous femoral and SNB provides a superior opioid sparing effect and improves analgesia after TKA.

摘要

背景与目的

在全膝关节置换术后,添加坐骨神经阻滞(SNB)以改善镇痛效果的益处尚不确定。我们假设单次注射 SNB 的有效持续时间太短,无法改善术后镇痛效果,这也是导致 SNB 在 TKA 后疗效存在争议的原因。我们在一项前瞻性、双盲、随机对照试验中对此假设进行了评估。

方法

60 例接受 TKA 的患者被随机分配至连续 SNB 组或单次注射 SNB 组。所有患者均接受股神经阻滞(0.5%罗哌卡因 20 mL)和 SNB(0.2%罗哌卡因 20 mL),并在手术前将导管插入外周神经阻滞部位。两组患者均接受连续股神经阻滞和吗啡患者自控静脉镇痛。术后,连续 SNB 组(0.2%罗哌卡因 5 mL/h;连续 SNB 组)或假连续 SNB 组(0.9%生理盐水 5 mL/h;单次注射 SNB 组)提供连续 SNB。主要结局为术后 48 小时内的总吗啡消耗量。

结果

与单次注射 SNB 组相比,连续 SNB 组术后 48 小时内的总吗啡消耗量显著降低[4.9(5.9)mg 比 9.7(9.5)mg,P = 0.002]。连续 SNB 组静息时的视觉模拟评分疼痛也显著降低(P = 0.035)。

结论

连续股神经和 SNB 的联合应用可提供更好的阿片类药物节省效果,并改善 TKA 后的镇痛效果。

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