Yamaguchi Yuji, Kashima Hideaki, Fukuba Yoshiyuki, Hayashi Naoyuki
Graduate School of Human-Environment Studies, Kyushu University, Kasuga, Fukuoka, 816-8580, Japan.
J Physiol Sci. 2014 May;64(3):195-201. doi: 10.1007/s12576-014-0311-1. Epub 2014 Mar 30.
The effect of static exercise on neurovascular coupling (NVC) was investigated by measuring the blood flow velocity in the posterior cerebral artery (PCAv) during 2-min static handgrip exercises (HG) at 30 % of the maximum voluntary contraction in 17 healthy males. NVC was estimated as the relative change in PCAv from eye closing to a peak response to looking at a reversed checkerboard. The conductance index (CI) was calculated by dividing PCAv by the mean arterial pressure (MAP). HG significantly increased PCAv from the resting baseline, with an increase in MAP and a reduction in CI, whereas NVC did not differ significantly between the resting and HG. Compared to the resting baseline, HG significantly increased the pressor response to visual stimulation by 5.6 ± 1.1 (mean ± SE) mmHg, while the CI response was significantly inhibited by -7.0 ± 1.5 %. These results indicate that NVC was maintained during HG via contributions from both the pressor response and vasodilatation.
通过在17名健康男性进行最大自主收缩30%的2分钟静态握力运动（HG）期间测量大脑后动脉（PCAv）的血流速度，研究了静态运动对神经血管耦合（NVC）的影响。NVC被估计为从闭眼到观看反转棋盘的峰值反应期间PCAv的相对变化。传导指数（CI）通过将PCAv除以平均动脉压（MAP）来计算。HG使静息基线时的PCAv显著增加，同时MAP升高而CI降低，而静息和HG期间NVC无显著差异。与静息基线相比，HG使视觉刺激的升压反应显著增加5.6±1.1（平均值±标准误）mmHg，而CI反应被显著抑制-7.0±1.5%。这些结果表明，在HG期间，通过升压反应和血管舒张的共同作用维持了NVC。
