用于治疗药物递送的纳米材料的设计、合成和功能化。

Design, synthesis, and functionalization of nanomaterials for therapeutic drug delivery.

机构信息

Biomedical Engineering, School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, USA.

出版信息

Adv Exp Med Biol. 2014;811:157-82. doi: 10.1007/978-94-017-8739-0_9.

Abstract

Nanomaterials have the potential to solve some of the toughest challenges facing modern medicine. Their unique optical, magnetic and chemical properties at the nanoscale make them different from their macroscale counterparts. Successful application of nanomaterials can revolutionize therapeutics, diagnostics and imaging in several biomedical applications. Self-assembled amphiphilic polymeric nanoparticles have been employed to carry poorly soluble chemotherapeutic drugs. Loading of anticancer chemotherapeutic drugs into self assembled polymeric nanoparticles have shown to increase their circulation time, tumor localization and therapeutic potential. This book chapter provides an introductory discussion to organic nanotechnologies for drug delivery. Promising advances in the field of nanomedicine will be discussed and an outlook to the future will be provided.

摘要

纳米材料具有解决现代医学面临的一些最严峻挑战的潜力。它们在纳米尺度上具有独特的光学、磁性和化学性质，与宏观尺度的对应物不同。成功应用纳米材料可以彻底改变几种生物医学应用中的治疗、诊断和成像。自组装两亲性聚合物纳米粒子已被用于携带疏水性化疗药物。将抗癌化疗药物载入自组装聚合物纳米粒子中，已显示出增加其循环时间、肿瘤定位和治疗潜力。本章提供了药物传递用有机纳米技术的介绍性讨论。将讨论纳米医学领域的有希望的进展，并提供对未来的展望。