Moritz Michał, Geszke-Moritz Małgorzata
Recent Developments in the Application of Polymeric Nanoparticles as Drug Carriers.
NanoBioMedical Centre, Adam Mickiewicz University, Poznań, Poland.
Adv Clin Exp Med. 2015 Sep-Oct;24(5):749-58. doi: 10.17219/acem/31802.
Nanotechnology is an interdisciplinary field of science offering interesting solutions for many branches of human life. Nanomaterials, defined as structures with at least one dimension below 100 nm, are the focus of increasing research attention as versatile tools for nanomedicine. Among the various nanostructures recently described in the literature, polymeric nanoparticles, characterized by satisfying biocompatibility, have aroused great interest as the carriers for various biologically active substances such as drugs, proteins and nucleic acids. These nanoparticles have already been reported as efficient vehicles for therapeutic agents in many disease entities. They can be delivered to the body via different administration routes. This review addresses recent advances in the usage of polymeric nanoparticles as drug carriers described in the years 2013 and 2014. The advantages of polymeric nanocarriers for medical application are highlighted, including their low toxicity, evaluated in vitro and in vivo. Moreover, the classification of polymeric nanoparticles is presented as well as various protocols of their synthesis.
纳米技术是一个跨学科的科学领域，为人类生活的许多分支提供了有趣的解决方案。纳米材料被定义为至少有一个维度低于100纳米的结构，作为纳米医学的通用工具，正日益成为研究关注的焦点。在最近文献中描述的各种纳米结构中，具有良好生物相容性的聚合物纳米颗粒作为药物、蛋白质和核酸等各种生物活性物质的载体引起了极大的兴趣。这些纳米颗粒已被报道为许多疾病实体中治疗剂的有效载体。它们可以通过不同的给药途径递送至体内。本综述阐述了2013年和2014年所描述的聚合物纳米颗粒作为药物载体应用的最新进展。强调了聚合物纳米载体在医学应用中的优势，包括其在体外和体内评估的低毒性。此外，还介绍了聚合物纳米颗粒的分类及其各种合成方案。
